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ProteomicsSulfamate acetamides as self-immolative electrophiles for covalent ligand- directed release chemistry - Pull Down data
Electrophiles for covalent inhibitors that are suitable for in vivo administration are rare. While acrylamides are prevalent in FDA approved covalent drugs, chloroacetamides are considered too reactive for such purposes. We report sulfamate-based electrophiles that maintain chloroacetamide-like geom...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038375 | Pride
Human Pull down Chemical probes 
ProteomicsSulfamate acetamides as self-immolative electrophiles for covalent ligand- directed release chemistry
Electrophiles for covalent inhibitors that are suitable for in vivo administration are rare. While acrylamides are prevalent in FDA approved covalent drugs, chloroacetamides are considered too reactive for such purposes. We report sulfamate-based electrophiles that maintain chloroacetamide-like geom...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038301 | Pride
Human Chemical probes Isodtb 
UnknownSulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry.
Not available
S-EPMC9936582 | biostudies-literature
ProteomicsU2OS cells EL133 and Bardoxolone
U2OS cells were incubated with DMSO at 0.1% or with compound for 20 hours in quadruplicates. Following incubation, the cells were lysed in a mixed detergent buffer (Cells were lysed using detergent based buffer containing the following: (50mM HEPES pH 8.0, 1% SDS, 1% Triton X-100, 1% NP-40, 1% Tween...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067656 | Pride
Human Lc-ms/ms 
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