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ProteomicsImmunopeptidomics analysis of human atherosclerosis plaques identifies antigenic drivers of atherosclerosis
Atherosclerosis has an auto-immune component driven by self-reactive T and B cells. Identifying their antigenic drivers may lead to new diagnosis and treatment approaches. Here, we aim to identify immunogenic T cell epitopes derived from atherosclerosis-relevant proteins such as ApoB100 by studying ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD068446 | Pride
Immunopeptidomics Pbmcs Apob100 Antigen-specific t cells 
ProteomicsDevelopment of covalent probes to capture Legionella pneumophila effector enzymes
Upon infection of host cells Legionella pneumophila releases a multitude of effector enzymes into the hosts cytoplasm that hijack a plethora of cellular activities, including the hosts ubiquitination pathways. Effectors belonging to the SidE-family are involved in non-canonical serine phosphoribosyl...
ORGANISM(S): Homo sapiens (Human) Legionella pneumophila subsp. pneumophila Lp02 
2025-05-06 | PXD049797 | Pride
Legionella pneumophila Activity-based probe Ubiquitylation Adp-ribosylation Bacterial infection 
ProteomicsDevelopment of inhibitors, probes, and PROTAC provides a complete toolbox to study PARK7 in the living cell
The innovation of combined chemical tools, such as small molecule inhibitors, activity-based probes (ABPs), and proteolysis targeting chimeras (PROTACs) for a specific target, not only advances clinical drug discovery but also provides a chemical toolbox to study the diverse biological perspective o...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047093 | Pride
Park7 Small molecule inhibitors Protacs Activity-based probes 
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