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MetabolomicsSex differences modulate the serum metabolome profiles in Parkinson’s disease patients harbouring pathogenic mutations in GBA1, LRRK2, TMEM175, PARK2, PINK1, and PARK7 genes

Background: Sex and genetic background have an impact on Parkinson’s disease (PD) insurgence, but the comprehension of how these factors affect the circulating profile of PD patients is still an aim of study.

Objectives: In this study we aimed to investigate whether genetic background and ...

2026-06-26 | MTBLS12753 | MetaboLights
MetabolomicsEffect of PARK7 gene KO on midbrain organoids
Not available
ORGANISM(S): Homo sapiens 
ST002327 | MetabolomicsWorkbench
ProteomicsParkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
Early-onset Parkinson's disease can be caused by mutations in the gene PARK7. Many functions have been proposed for PARK7, but in vivo evidence is largely lacking or conflicting with enzymological data. Here, we provide unequivocal evidence that PARK7 and its orthologues can prevent damage of protei...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Oryctolagus cuniculus (Rabbit) Saccharomyces cerevisiae (Baker's yeast) Drosophila melanogaster (Fruit fly) 
2022-01-26 | PXD029410 | Pride
Dj1 Phosphoglycerate Phosphoglyceroyl Glycolysis Parkinson's disease Glycerate Glyceroyl Park7 Posttranslational modification 
ProteomicsDevelopment of inhibitors, probes, and PROTAC provides a complete toolbox to study PARK7 in the living cell
The innovation of combined chemical tools, such as small molecule inhibitors, activity-based probes (ABPs), and proteolysis targeting chimeras (PROTACs) for a specific target, not only advances clinical drug discovery but also provides a chemical toolbox to study the diverse biological perspective o...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047093 | Pride
Park7 Small molecule inhibitors Protacs Activity-based probes 
GenomicsHelgueta Park7
Park7 deletion leads to age- and sex-specific transcriptome changes in mouse midbrain astrocytes
PRJEB59115 | ENA
GenomicsPARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
PRJNA1078263 | ENA
GenomicsPARK7/DJ-1 deficiency modulates microglial activation in response to LPS-induced inflammation
PARK7/DJ-1 deficiency modulates microglial activation in response to LPS-induced inflammation
PRJNA1071524 | ENA
UnknownPark7 expression influences myotube size and myosin expression in muscle.
Not available
S-EPMC3956870 | biostudies-literature
TranscriptomicsPARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
Background: Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role during the underlying neuroinflammatory processes remain lar...
ORGANISM(S): Mus musculus 
2024-08-09 | GSE256105 | GEO
TranscriptomicsPARK7/DJ-1 deficiency modulates microglial activation in response to LPS-induced inflammation
Background: Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role during the underlying neuroinflammatory processes remain lar...
ORGANISM(S): Mus musculus 
2024-08-09 | GSE254687 | GEO
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