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ProteomicsParkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
Early-onset Parkinson's disease can be caused by mutations in the gene PARK7. Many functions have been proposed for PARK7, but in vivo evidence is largely lacking or conflicting with enzymological data. Here, we provide unequivocal evidence that PARK7 and its orthologues can prevent damage of protei...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Oryctolagus cuniculus (Rabbit) Saccharomyces cerevisiae (Baker's yeast) Drosophila melanogaster (Fruit fly) 
2022-01-26 | PXD029410 | Pride
Dj1 Phosphoglycerate Phosphoglyceroyl Glycolysis Parkinson's disease Glycerate Glyceroyl Park7 Posttranslational modification 
ProteomicsLFQ of 3-phosphoglyceroyl lysine peptides from WT and DJ-1 KO HeLa cells
WT or DJ-1 KO HeLa cells (n=3) were lysed in 500 μL of 6 M guanidine-HCl, 100 mM HEPES-NaOH, pH 7.5, 10 mM TCEP, and 40 mM CAA. The lysates were dissolved by heating and sonication, followed by centrifugation at 20,000 x g for 15 min at 4 ºC. The supernatants were recovered and proteins (1 mg each) ...
ORGANISM(S): Homo Sapiens (human) 
2025-05-07 | PXD063699 | JPOST Repository
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