Sort   by:  
 Page size 
MetabolomicsSubcellular organelle lipidomics in TLR-4-activated macrophages
Not available
ORGANISM(S): Mus musculus 
ST001288 | MetabolomicsWorkbench
MetabolomicsOverexpression of tlr5 adrffects gut microbiota resistance to Salmonella infection

BACKGROUND: The gut microbiome and the host immune system interact synergistically to maintain intestinal health and defend against infections. Toll-like receptor 5 (TLR5), known for recognizing bacterial flagellin, plays a pivotal role in this regulatory network. Despite significant advances in ...

2024-07-25 | MTBLS10592 | MetaboLights
MetabolomicsGut commensal Odoribacter splanchnicus alleviates hyperlipidemic periodontitis via the β-GPA-TLR4 axis

Background: Hyperlipidemia is a well-established systemic metabolic disorder and a significant risk factor for periodontitis, a localized inflammatory condition; however, the precise mechanisms underpinning this comorbidity remain uncharacterized. Emerging evidence implicates the gut microbiota ...

2026-06-08 | MTBLS13135 | MetaboLights
MetabolomicsGut commensal Odoribacter splanchnicus alleviates hyperlipidemic periodontitis via the β-GPA-TLR4 axis

Background: Hyperlipidemia is a well-established systemic metabolic disorder and a significant risk factor for periodontitis, a localized inflammatory condition; however, the precise mechanisms underpinning this comorbidity remain uncharacterized. Emerging evidence implicates the gut microbiota a...

2026-06-08 | MTBLS13125 | MetaboLights
Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
MetabolomicsReleased palmitic acid–mediated TLR4/NF-κB activation enhances the virulence of Bordetella pertussis MT28 lineage

Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...

2025-12-21 | MTBLS13545 | MetaboLights
MetabolomicsPalmitic acid-mediated TLR4/NF-κB activation drives the pathogenicity of hypervirulent Bordetella pertussis MT28 lineage

Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...

2025-06-21 | MTBLS12625 | MetaboLights
MetabolomicsPlatycodin D attenuates alcohol-associated fatty liver disease by suppressing TLR4–NF-κB and activating PPAR signaling

Alcohol-associated fatty liver disease (AFLD) is driven by ethanol-induced metabolic dysregulation and hepatic inflammation, with gut dysbiosis and endotoxin-triggered innate immune activation implicated in disease progression. Platycodin D (PD), a triterpenoid saponin from Platycodon grandifloru...

2026-01-12 | MTBLS13658 | MetaboLights
MetabolomicsMicrobial-derived Hyodeoxycholic Acid Ameliorates Painful Diabetic Neuropathy by Modulating Dorsal Root Ganglion TLR4-Mediated Neuroinflammation Signaling Pathway

BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...

2026-08-24 | MTBLS12087 | MetaboLights
TranscriptomicsMacrophages recognize the Helicobacter pylori type IV secretion system in the absence of TLR signaling
Helicobacter pylori conquered the world by colonizing the human stomach. There are two major groups of strains, one with and one without a cag pathogenicity island (cagPAI), which result in different clinical outcomes with increased severity in cagPAI+ H. pylori infections such as higher inflammatio...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-56791 | biostudies-arrayexpress
Sort   by:  
 Page size