Background: Hyperlipidemia is a well-established systemic metabolic disorder and a significant risk factor for periodontitis, a localized inflammatory condition; however, the precise mechanisms underpinning this comorbidity remain uncharacterized. Emerging evidence implicates the gut microbiota a...
Background: Hyperlipidemia is a well-established systemic metabolic disorder and a significant risk factor for periodontitis, a localized inflammatory condition; however, the precise mechanisms underpinning this comorbidity remain uncharacterized. Emerging evidence implicates the gut microbiota ...
Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...
Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...
BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...
BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...
Alcohol-associated fatty liver disease (AFLD) is driven by ethanol-induced metabolic dysregulation and hepatic inflammation, with gut dysbiosis and endotoxin-triggered innate immune activation implicated in disease progression. Platycodin D (PD), a triterpenoid saponin from Platycodon grandifloru...
This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...
A combination of bioinformatics and network pharmacology was used to screen curcumin's target genes and related signaling pathways in treating hepatocellular carcinoma. Curcumin-Containing Serum（CUR） was prepared. Cisplatin(CDDP) served as the positive control .The CCK-8 assay, scratch assay, and...
