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Proteomics16-plex isobaric mass tags enable streamlined proteomics-based drug mechanism-of-action studies
Multiplexed quantitative proteomics enables the development of complex workflows for studying the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures changes in protein thermal st...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD020827 | Pride
Tmtpro Isobaric labeling 2d-tpp Tmt Mpdp Tpp 
Proteomics16-plex isobaric mass tags enable streamlined proteomics-based drug mechanism-of-action studies
Multiplexed quantitative proteomics enables the development of complex workflows for studying the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures changes in protein thermal st...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD020830 | Pride
Tmtpro Isobaric labeling 2d-tpp Tmt Mpdp Tpp 
Proteomics16-plex isobaric mass tags enable streamlined proteomics-based drug mechanism-of-action studies
Multiplexed quantitative proteomics enables the development of complex workflows for studying the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures changes in protein thermal st...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD020829 | Pride
Tmtpro Isobaric labeling 2d-tpp Tmt Mpdp Tpp 
Proteomics16-plex isobaric mass tags enable streamlined proteomics-based drug mechanism-of-action studies
Multiplexed quantitative proteomics enables the development of complex workflows for studying the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures changes in protein thermal st...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD020831 | Pride
Tmtpro Isobaric labeling 2d-tpp Tmt Mpdp Tpp 
Proteomics16-plex isobaric mass tags enable streamlined proteomics-based drug mechanism-of-action studies
Multiplexed quantitative proteomics enables the development of complex workflows for studying the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures changes in protein thermal st...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD020828 | Pride
Tmtpro Isobaric labeling 2d-tpp Tmt Mpdp Tpp 
Proteomics16-plex isobaric mass tags enable streamlined proteomics-based drug mechanism-of-action studies
Multiplexed quantitative proteomics enables the development of complex workflows for studying the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures changes in protein thermal st...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2021-02-25 | PXD020848 | Pride
Tmtpro Isobaric labeling 2d-tpp Tmt Mpdp Tpp 
ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-01-29 | MSV000084859 | MassIVE
ProteomicsTMT-labeling and mass spectrometry analysis of Trypanosoma cruzi life cycle stages
Quantitative proteomic analysis by 16-plex tanden mass tag (TMT)-labeling and mass spectrometry of Trypanosoma life cycle stages. Analysis were performed with T. cruzi epimastigotes, column purified metacyclic trypomastigotes, amastigotes, cell culture-derived trypomastigotes. Four biological replic...
ORGANISM(S): Trypanosoma cruzi 
2025-11-11 | PXD061891 | Pride
Quantitative proteomics Tmt-labeling Trypanosoma cruzi 
ProteomicsTMTpro: Design and initial evaluation of a novel Proline-based isobaric 16-plex Tandem Mass Tag reagent set
The design and synthesis of a novel proline-reporter-based isobaric Tandem Mass Tag 16 tag set (TMTpro) was carried out and the data uploaded here is a comparison of the performance of the new TMTpro tags with the current commercially available dimethylpiperidine-reporter-based TMT10/11 reagents. Da...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Rattus norvegicus (Rat) 
2019-11-25 | PXD014750 | Pride
Tmt Tmtpro 
ProteomicsAutomated sample preparation workflow for tandem mass tag-based proteomics
Although tandem mass tag (TMT)-based isobaric labeling has become a powerful technique for multiplexed protein quantitation, it has not been easy to automate the workflow for widespread adoption. This is because preparation of TMT labeled peptide samples involves multiple steps ranging from protein ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040788 | Pride
Automation Tandem mass tags Proteomics 
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