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ProteomicsTMX2 is a key regulator of cellular redox state and its dysfunction causes severe brain developmental abnormalities.
The redox state of the neural progenitors regulates physiological processes such as neuronal differentiation, dendritic and axonal growth. The relevance of ER-associated oxidoreductases in these processes is largely unexplored. We describe a severe neurological disorder caused by biallelic loss of f...
ORGANISM(S): Homo sapiens (Human) 
2019-11-19 | PXD014064 | Pride
Tmx2 Brain developmental abnormalities Redox state 
GenomicsTMX2 is a key regulator of cellular redox state and its dysfunction causes severe brain developmental abnormalities
TMX2 is a key regulator of cellular redox state and its dysfunction causes severe brain developmental abnormalities
PRJNA551587 | ENA
TranscriptomicsTMX2 is a key regulator of cellular redox state and its dysfunction causes severe brain developmental abnormalities
The redox state of the neural progenitors regulates physiological processes such as neuronal differentiation, dendritic and axonal growth. The relevance of ER-associated oxidoreductases in these processes is largely unexplored. We describe a severe neurological disorder caused by biallelic loss of f...
ORGANISM(S): Homo sapiens 
2019-12-31 | GSE133483 | GEO
UnknownTMX2 potentiates cell viability of hepatocellular carcinoma by promoting autophagy and mitophagy.
Not available
S-EPMC11423672 | biostudies-literature
UnknownThioredoxin-related transmembrane protein 2 (TMX2) regulates the Ran protein gradient and importin-β-dependent nuclear cargo transport.
Not available
S-EPMC6814788 | biostudies-literature
UnknownTMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities.
Not available
S-EPMC6904804 | biostudies-literature
UnknownRecurrent homozygous damaging mutation in <i>TMX2</i>, encoding a protein disulfide isomerase, in four families with microlissencephaly.
Not available
S-EPMC7405652 | biostudies-literature
ProteomicsThe ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
Our study demonstrates that ERMCS-localized TMX2 enhances the antioxidant activity of PRDX1/2 on TOM70, thereby preventing sulfenylation of TOM70 at C206 and regulating mitochondrial metabolism.
ORGANISM(S): Homo Sapiens (human) 
2025-10-31 | PXD057380 | JPOST Repository
UnknownHigh-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines.
Not available
S-EPMC3962540 | biostudies-literature
UnknownThe non-canonical thioreductase Tmx2b is essential for neuronal survival during zebrafish embryonic brain development.
Not available
S-EPMC12516324 | biostudies-literature
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