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MetabolomicsSerum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflammation and prevent destruction of the joint. RA is a heterogeneous disease,...
2025-08-14 | MTBLS6213 | MetaboLights
ProteomicsExtracellular vesicles proteomic profile in anti-TNF immunosuppressed mice: insights into protein dysregulation during Leishmania infantum infection
Visceral leishmaniasis (VL) is most frequent in immunosuppressed patients, especially among those receiving immunosuppressive therapy for autoimmune diseases, being TNF antagonist (anti-TNF) one of the main immunosuppressants used. Under these conditions, VL is most severe, with lower response to tr...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-22 | PXD060935 | Pride
Antimonials Visceral leishmaniasis Immunosuppression Extracelullar vesicles Quantitative proteomics Biomarkers Tnf antagonist 
TranscriptomicsGene expression analysis of TNF-alpha stimulated CaCo-2 cells
The series was designed to obtain gene expression patterns of TNF-alpha stimulated CaCo-2 cells. Keywords: TNF-alpha stimulation This series represents a group of 18 samples in 2 groups: 10 samples derived from not stimulated CaCo-2 cells, 8 samples from CaCo-2 cells stimulated with TNF-alpha in fin...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10108 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TNF-alpha stimulated THP-1 cells
The series was designed to obtain gene expression patterns of TNF-alpha stimulated THP-1 cells. Keywords: TNF-alpha stimulation This series represents a group of 15 samples in two groups: 7 samples derived from not stimulated THP-1 cells, 8 from THP-1 cells stimulated with TNF-alpha in a final conce...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10106 | biostudies-arrayexpress
GenomicsIncreased AIF-1-mediated TNF-α expression during the implantation phase in IVF cycles with GnRH antagonist protocol
Increased AIF-1-mediated TNF-α expression during the implantation phase in IVF cycles with GnRH antagonist protocol
PRJNA421929 | ENA
TranscriptomicsTranscription profiling of doxazosin response, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH)
BACKGROUND: We used cDNA microarray analysis to obtain insights into the mechanisms of action of doxazosin, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH). METHODS: Hierarchical clustering analysis and significance analysis of microarray (SAM) were perfor...
ORGANISM(S): Homo sapiens 
2005-11-07 | E-SMDB-2934 | biostudies-arrayexpress
UnknownRandomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions.
Not available
S-EPMC5824923 | biostudies-literature
UnknownTNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.
Not available
S-EPMC8813949 | biostudies-literature
UnknownTrivalent soluble TNF Receptor, a potent TNF-α antagonist for the treatment collagen-induced arthritis.
Not available
S-EPMC5943350 | biostudies-literature
TranscriptomicsIncreased AIF-1-mediated TNF-α expression during the implantation phase in IVF cycles with GnRH antagonist protocol
Administration of GnRH antagonist in IVF has several advantages. However, studies have shown that GnRH antagonist protocol cycles have lower implantation and clinical pregnancy rates than GnRH agonist long protocol cycles. Endometrial receptivity rather than embryo quality is thought to account for ...
ORGANISM(S): Homo sapiens 
2018-06-27 | GSE107914 | GEO
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