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TranscriptomicsGene Expression Profiling of Patients with a Variation in the TNF-alpha gene and suffering from Multiple Trauma
BACKGROUND: Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We undertook a prospective cohort study of trauma patients to examine the role of tumor...
ORGANISM(S): Homo sapiens 
2007-08-22 | E-GEOD-5760 | biostudies-arrayexpress
ModelsHayashi2013 - TNF-induced Signaling Dynamics (Model A)
Hayashi2013 - TNF-induced Signaling Dynamics Model (Model A) Tumor necrosis factor (TNF) plays a crucial role in inflammation and is associated with diseases such as rheumatoid arthritis and cancer. While TNF signaling pathways are well studied, targeted regulation of proinflammatory responses rem...
2025-02-19 | MODEL2502170001 | BioModels
TranscriptomicsmRNA regulation in normal or TNF-a/IL-4-activated bronchial epithelial cells (BEAS-2B)
Illumina microarray experiment on BEAS-2B cells. Cells were seeded 24 h before TNF-a/IL-4 (50 ng/ml) treatment that lasted for 18 h. Cytoplasmic RNA of both normal and activated BEAS-2B cells were collected for microarray. Cells were seeded 24 h before TNF-a/IL-4 (50 ng/ml) treatment that lasted f...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-13119 | biostudies-arrayexpress
TranscriptomicsMiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA
We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels. Transcriptional profiling of genes in response to either a miR-26 mimic or miR-26 antagomir.
ORGANISM(S): Homo sapiens 
2016-03-31 | E-GEOD-70831 | biostudies-arrayexpress
TranscriptomicsWhole blood transcriptional profiling of healthy volunteers and rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy after ex vivo whole blood stimulation with TNF
We tested the hypothesis that anti-tumor necrosis factor (TNF) therapy reduces TNF-inducible gene expression in blood. Whole peripheral blood from healthy volunteers and rheumatoid arthritis patients (treated with the monoclonal anti-TNF antibody adalimumab, the soluble TNF receptor etanercept or th...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5094 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis Identifies Fn14, a TNF Superfamily Receptor Member, as a Therapeutic Target in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease and occurs in patients with excessive alcohol intake It is characterized by marked hepatocellular damage, steatosis and pericellular fibrosis. Patients with severe AH have a poor short-term prognosis. Unfortunately, current ...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-28619 | biostudies-arrayexpress
TranscriptomicsExpression data from TNF-stimulated mouse glomeruli
The specific contribution of the two TNF-receptors Tnfr1 and Tnfr2 to TNF-induced inflammation in the glomerulus is unknown. In mice, TNF exposure induces glomerular expression of inflammatory mediators like adhesion molecules and chemokines in vivo, and glomerular accumulation of leukocytes. To exa...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-43928 | biostudies-arrayexpress
ProteomicsPhosphoproteome profiling uncovers a key role for CDKs in TNF signaling
Tumor necrosis factor (TNF) is one of the few cytokines successfully targeted by therapies against inflammatory diseases. However, blocking this well studied and pleiotropic ligand can cause dramatic side-effects. We reasoned that a systems-level proteomic analysis of TNF signaling could dissec...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-10-11 | PXD021366 | Pride
Necroptosis Transcription Kinases Apoptosis Phosphoproteomics Spatial proteomics Cyclin-dependent kinases Tnf Cell death 
TranscriptomicsCoordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
Steady-state gene expression is a coordination of synthesis and decay of RNA through epigenetic regulation, transcription factors, miRNAs, and RNA-binding proteins. Here, we present Bru-Seq and BruChase-Seq to assess genome-wide changes to RNA synthesis and stability in human fibroblasts at homeosta...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-43440 | biostudies-arrayexpress
TranscriptomicsHuman annulus disc cells grown in a 3D collagen sponge and exposed to TNF-a
The objective of this study was to determine how TNF-a, an important proinflammatory cytokine, affects gene expression in the human annulus. Cells were grown in a 3D collagen construct for 14 days with TNF-a. mRNA was isolated and subjected to microarray. Fold changes in gene expression were determ...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41883 | biostudies-arrayexpress
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