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TranscriptomicsTranscription profiling by array of siRNA transfected HEK293T cells untreated or treated with TNF-alpha to study the effect of siRNA-mediated knockdown of different genes
HEK293T cells were treated with TNF-alpha for different periods of time to study the effect of siRNA-mediated knockdown of different genes (negative control: Renilla luciferase; positive controls: TNFRSF1A, RelA; gene of interest: CASP4) on TNF-induced gene expression
ORGANISM(S): Homo sapiens 
2012-07-06 | E-MTAB-900 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on adult Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16261 | biostudies-arrayexpress
TranscriptomicsIntegrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
We sought to provide a comprehensive evaluation of the effects of TNF-α and IL-17 on the keratinocyte gene profile in order to identify genes that might be co-regulated by these cytokines. We then sought to determine how genes that were synergistically activated by both cytokines relate to the psori...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-24767 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of skeletal myoblast differentiation and exposure to TNF-alpha or IGF1
Skeletal myocyte differentiation involves fusion of myoblasts to multinucleated myotubes. In vitro differentiation can be induced by serum withdrawal. The differentiation process is negatively regulated by pathological concentrations of TNF-alpha but can be positively regulated by IGF1. This study f...
ORGANISM(S): Mus musculus 
2015-04-05 | E-MTAB-3474 | biostudies-arrayexpress
ProteomicsDifferential protein secretome induced by TNF-alpha
Endothelial-mesenchymal-transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which are known to facilitate tumor progression. We have previously shown that EndMT is present in pancreatic tumors and that deficiency of the Tie1 receptor induces EndMT in human endothelial ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014488 | Pride
Tnfalpha Cancer Secretome Mesenchymal cell Lc-ms Endothelial cell 
TranscriptomicsTranscriptomic analysis of human skin Langerhans cell and dermal dendritic cells stimulated in vitro with TNF-alpha
Langerhans cells (LCs) are antigen presenting cells residing in the epidermis. Due to the difficulties with obtaining sufficient quantities of LCs for functional studies, many controversies exist about their origin and function. To gain insights into the molecular mechanisms underpinning LC biology ...
ORGANISM(S): Homo sapiens 
2013-12-08 | E-GEOD-49475 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in peripheral blood cells of patients with rheumatoid arthitis in response of anti-TNF-alpha
The goal of this study was to characterize the effects of anti-TNF-alpha treatments on gene expression in peripheral blood mononuclear cells. 8 women were submitted to a 12 weeks treatments with Etanercept or Adalimumab. Peripheral blood mononuclear cells were taken before and after the treatment. ...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-12897 | biostudies-arrayexpress
TranscriptomicsThe effects of terbutaline or GW9508 on TNF-alpha and IFN gamma (TNF-alpha + IFN gamma) stimulation by HaCaT
G-protein coupled receptors (GPCRs) have diverse roles in physiological processes, including immunity. Gs-coupled GPCRs increase while Gi-coupled ones decrease intracellular cAMP. Previous studies suggest that, in epithelial cells, Gs-coupled GPCRs enhance whereas Gi-coupled GPCRs suppress pro-infl...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-20297 | biostudies-arrayexpress
TranscriptomicsKBM7 genetrap mutant cells stimulated with TNF-alpha and IFN-gamma
Transcriptional response of KBM7 cells to IFN-gamma or TNF-alpha was investigated in control or cells with genetrap insertions in JAK2 or TNFRS1A, respectively. The experiment shows that, as expected, cells lacking JAK2 or TNFRS1A expression display a severly blunted response to the tested cytokines...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-48848 | biostudies-arrayexpress
TranscriptomicsTrap-80-dependence of TNF-alpha-induced genes
In fibroblasts, p65-dependent genes can be sub-divided, depending on whether they are Trap-80-dependent or -independent. To examine the generality of this grouping, we performed a microarray analysis of wild-type and Trap-80 knock-down fibroblasts, before and after stimulation of NF-kappaB activity...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-12697 | biostudies-arrayexpress
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