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ProteomicsTankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death
TNF is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes production of other cytokines via a membrane-bound complex 1, or induces cell death via a cytosolic complex 2. To understand how TNF-induced cell death is regulated we performed mass spectrometry o...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD032131 | Pride
Tnf-induced cell death Tankyrase Adp-ribosylation 
GenomicsIL1A enhances TNF-induced retinal ganglion cell death
IL1A enhances TNF-induced retinal ganglion cell death
PRJNA1418622 | ENA
ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
2024-10-15 | PXD056836 |
GenomicsHERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
PRJNA1418570 | ENA
GenomicsA20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death [human]
A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death [human]
PRJNA526883 | ENA
GenomicsA20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death [mouse]
A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death [mouse]
PRJNA526882 | ENA
UnknownTBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Not available
S-EPMC6268100 | biostudies-literature
TranscriptomicsPKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells
A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the ac...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-44747 | biostudies-arrayexpress
UnknownLUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Not available
S-EPMC6156229 | biostudies-literature
TranscriptomicsIL1A enhances TNF-induced retinal ganglion cell death
Introduction: A growing body of literature suggests a role for neuroinflammation in retinal ganglion cell (RGC) death in glaucoma. For instance, deficiency of three proinflammatory cytokines, complement component 1, subcomponent q (C1q), interleukin 1 alpha (Il1a), and tumor necrosis factor (Tnf), r...
ORGANISM(S): Mus musculus 
2026-02-04 | GSE318351 | GEO
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