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TranscriptomicsMll1 regulates the downstream gene transcription activated by TNFa
Genes of mixed lineage leukemia family regulate transcription via methylating histone H3K4. we studied the role of MLL1 in innate immunity and found it selectively regulates the activation of NF-kB downstream genes mediated by TNFa. Mll1+/+ and Mll1-/- MEF cells were treated for 4 hr with 10ng/ml TN...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36567 | biostudies-arrayexpress
TranscriptomicsThe effect of TNFa on endothelial cells
To understand the transcripts induced by TNFa and how these may interact in inflammatory networks, the transcriptome of HUCECs stimulated with TNFa was examined in 3 different pools each cosisting of 10 different HUVEC isolates. In the study present here, HUVEC isolates from 3 pools of 10 different ...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27870 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Calu-3 2B-4 cells stimulated with Interleukin-1a and TNFa.
Calu-3 2B-4 cells were stimulated with interleukin-1a or TNFa. Transcriptional analysis of the extracted RNA was done by microarray. Calu-3 2B-4 cells were washed with phosphate-buffered saline (PBS) and treated with either IL-1a (0.001ng/ml) or TNFa (0.05ng/ml) or mock diluted in PBS for 40 min at...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56678 | biostudies-arrayexpress
ProteomicsProteomic analyisis of cultured human podocytes stimulated with TNFa - supernatant
TNFa stimulated human cultured podocytes compared with unstimulated (vehicle control (VC)) podocytes. Incubation of podocytes with high concentrations of TNF alpha led to an overexpression of ICAM1 in particular. We studied this system as a comparator for organoids also stimulated with the same conc...
ORGANISM(S): Homo sapiens (Human) 
2023-05-19 | PXD032130 | Pride
Inflammation Podocytes Inflammatory response Cytokines 
ProteomicsDEPC labeling of TNFa - antibody complexes
Covalent labeling mass spectrometry measurements of complexes of tumor necrosis alpha (TNFa) with different antibodies.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-12 | MSV000088376 | MassIVE
ProteomicsProteomic analyisis of cultured human podocytes stimulated with TNFa - cell pellet
TNFa stimulated human cultured podocytes compared with unstimulated (vehicle control (VC)) podocytes. Incubation of podocytes with high concentrations of TNF alpha led to an overexpression of ICAM1 in particular. We studied this system as a comparator for organoids also stimulated with the same conc...
ORGANISM(S): Homo sapiens (Human) 
2023-05-19 | PXD032107 | Pride
Inflammation Podocytes Inflammatory response Cytokines 
TranscriptomicsGenome wide gene expression profiles of distal colon from 5% DSS-treated mice after administration of various siRNA against TNFa.
Differential gene expression assessed in siTNF-OMe-P treated animals showed significant correlation between improved colon integrity and clinical parameters of colitis with reduced TLR activation, tissue regeneration and reduced pro-inflammatory cytokines, as compared to all treatment groups. This d...
ORGANISM(S): Mus musculus 
2011-09-09 | E-GEOD-31906 | biostudies-arrayexpress
TranscriptomicsPrimary human bone marrow-derived mesenchymal stem cells (MSCs) treated with TNFa ligand
Primary human bone marrow-derived mesenchymal stem cells (MSCs) were treated with recombinant human TNFa (50ng/ml) for different time points (1, 3, 7, 14, 24 hours)
ORGANISM(S): Homo sapiens 
2017-04-28 | E-MTAB-5421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat fibroblast-like synoviocyte cell cultures treated with TNFa and SB203580
Gene expression affected by TNFa was investigated, then, p38 inhibitor SB203580 was used to investigate p38 signal pathway. Experiment Overall Design: Fibroblast-like synoviocyte culture was treated with TNFa in the presence and absence of SB203580 and compared to the gene expression not treated wi...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7826 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptional profiles of WT and HOIL-1L-/- BMDMs in response to LPS and TNFa
HOIL-1L is an essential member of the linear ubiquitin assembly complex (LUBAC), which targets Nemo for linear ubiquitination during NF-kB activation in response to a variety of simuli, including LPS and TNFa treatment. HOIL-1L has also been suggested to function as a transcription factor. Here we a...
ORGANISM(S): Mus musculus 
2014-05-15 | E-GEOD-57180 | biostudies-arrayexpress
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