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ProteomicsUnveiling the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model
Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. The current study aims to understand how these variants affect cellular function at the phenotypic ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-01-12 | PXD060549 | Pride
Fly Juvenile granulosa cell tumors Akt1 Ovary 
ProteomicsModification of the transcription factor FOXL2 at serines 101 and 107 disables DNA binding, leads to nucleolar relocalization, and rewires granulosa-cell programs
FOXL2 is a forkhead transcription factor (TF) essential for granulosa-cell identity and function, yet how post-translational modifications tune its activity remains incompletely understood. Here, we show that protein kinase C phosphorylates FOXL2 in vitro. Two of the four phosphorylation sites, nota...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD076161 | Pride
Interactome Nucleolus Foxl2 phosphorylation Protein kinase c Transcriptome 
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