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ProteomicsReceptor-mediated recruitment of cytosolic J-proteins to the mitochondrial outer membrane promotes assembly of preprotein translocases
Mitochondria possess elaborate machineries for the import of preproteins from the cytosol. Cytosolic factors like Hsp70 chaperones and their co-chaperones, the J-proteins, guide preproteins to the mitochondrial surface. The translocase of the mitochondrial outer membrane (TOM) forms the entry gate f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-11-26 | PXD008203 | Pride
Proteomics Cytosolic j-proteins Yeast Mitochondria Silac 
UnknownRecruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis.
Not available
S-EPMC6280124 | biostudies-literature
GenomicsSolanum lycopersicum strain:Micro-Tom
Transcriptome analysis of a series of developing flower buds in tomato cv. Micro-Tom
PRJDB6494 | ENA
UnknownTom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress.
Not available
S-EPMC10927582 | biostudies-literature
ProteomicsTranslocase of the Outer Membrane (TOM complex) of hydrogenosomes in Trichomonas vaginalis
Mitochondria originated from α-proteobacterial endosymbionts, and the endosymbiont-to-organelle transition is tightly linked to the establishment of protein import pathways. The initial import of most proteins is mediated by the translocase of the outer membrane (TOM). Although TOM is common to all ...
ORGANISM(S): Trichomonas vaginalis G3 
2019-01-07 | PXD010850 | Pride
Mitochondria Tom complex Trichomonas vaginalis Protein import/translocation Hydrogenosomes 
TranscriptomicsRNase J is required for processing of a small number of RNAs in Rhodobacter sphaeroides
A comparative RNA-seq approach between R. sphaeroides 2.4.1 wild type and an RNase J deletion strain 2.4.1M-bM-^HM-^Frnj revealed the accumulation of different mRNA fragments in the mutant. The structural characteristics of these RNA fragments suggest that RNase J is responsible for the decay of deg...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2014-02-06 | E-GEOD-54750 | biostudies-arrayexpress
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
UnknownAtomic structure of human TOM core complex.
Not available
S-EPMC7522991 | biostudies-literature
ProteomicsDefinition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein (MAPL IP data)
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD062420 | Pride
Translocase of the outer mitochondrial membrane Ap-ms Mitochondria Protein import Quantitative mass spectrometry Hek293t cells 
ProteomicsDefinition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein (TOM20 IP data)
The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensiv...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD062418 | Pride
Translocase of the outer mitochondrial membrane Ap-ms Mitochondria Protein import Quantitative mass spectrometry Hek293t cells 
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