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ProteomicsMass spectrometry-based redox and protein profiling reveals distinct protein expression and oxidation patterns in failing human hearts
Oxidative stress plays a key role in development and progression of cardiovascular diseases and it is correlated with left ventricular dysfunction and heart failure (HF). Oxidative environments lead to the formation of intra- and intermolecular disulfide bonds, as well as to plethora of other revers...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021261 | Pride
Ischemic cardiomyopathy Myofibrilar proteins Heart failure Oxidative stress Dilated cardiomyopathy Redox proteomics 
ProteomicsEfficiency of acetate-based isopropanol synthesis in Escherichia coli W is controlled by ATP availability
Due to increasing ecological concerns, recombinant microbial production of biochemicals from sustainable carbon sources like acetate is rapidly gaining importance. However, for establishing successful large-scale production scenarios, a solid understanding of metabolic driving forces is required to ...
ORGANISM(S): Escherichia coli 
2024-10-17 | PXD047939 | Pride
Acetate Isopropanol Ecoli Bioingeneering Ecoli w 
ProteomicsProteome adaptations of AC16 cells different oxygen exposure
To simulate in vitro different oxidative stress exposures, AC16 cells were cultured either under physioxia (5% oxygen) or normoxia (21% oxygen), and were consequently harvested either under physioxia or normoxia.
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023620 | Pride
Heart Ac16 Oxidative stress 
ProteomicsA quantitative metabolic analysis reveals Acetobacterium woodii as a flexible and robust host for formate-based bioproduction
Cheap and renewable feedstocks such as the one carbon substrate formate are emerging for sustainable production in a growing chemical industry. By quantitatively analyzing physiology, transcriptome, proteome in chemostat cultivations in combination with computational analyses, we investigated the ac...
ORGANISM(S): Acetobacterium woodii 
2023-03-08 | PXD026569 | Pride
Mixed gas fermentation Continuous fermentation Metabolic modelling Substrate co-utilization Acetogens Omics analysis Formate bioeconomy 
ProteomicsProteomics profiling of end-stage COVID-19 diseased human lungs
Lung biopsies were collected from recently deceased patients, who tested positive and were treated for SARS-CoV-2 infections, or from patients that succumbed to a non-inflammatory unrelated disease, serving as control. Two samples were taken from each patient either from macroscopically affected lun...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD030009 | Pride
Covid Ards Pneumonia Lung 
ProteomicsGAPDH inhibition in A549 and H358 lung cancer cells
Human lung cancer cell lines A549 and H358 were obtained from (Biobank of Medical University of Graz) and cultured in RPMI 1640 (R0883; Sigma) supplemented with 10% fetal bovine serum (FBS; Gibco), 5 mM glutamine and 5 mM Pen Step, and sub-cultured regularly. For siRNA mediated knock-down of GAPDH, ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PXD061610 | Pride
Human Koningic acid Gapdh 
ProteomicsComprehensive investigation of (redox-) proteomic changes induced by cana-, dapa-, empagliflozin treatment in cardiac cells
One of the major macrovascular complications that can occur in type 2 diabetes is the development of cardiovascular diseases as for instance heart failure. However, sodium-glucose co-transporter-2 (SGLT-2) inhibitors have shortly after their approval shown to decrease death rates in diabetic patient...
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD063467 | Pride
Gliflozins Sglt-2 inhibitors Proteomics Ac16 cells Heart failure Oxidative stress Hcm cells Empagliflozin Redox proteomics Canagliflozin Dapagliflozin 
ProteomicsHuman platelet-derived extracellular vesicle proteome
The effect of size exclusion chromatography on the proteome of human platelet-derived extracellular vesicles was investigated.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024760 | Pride
Ev Timstof Sec 
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