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TranscriptomicsCulex quinquefasciatus Jpal-per strain vs. Ogasawara strain
A pyrethroid-resistant strain of Culex quinquefasciatus, JPal-per, exhibits 2500-fold greater larval resistance to permethrin than the insecticide-susceptible strain Ogasawara. An increased microsome monooxygenase metabolism is involved in the resistance mechanism. Microarray analysis revealed alter...
ORGANISM(S): Culex quinquefasciatus 
2010-06-24 | E-GEOD-17326 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
UnknownMitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis.
Not available
S-EPMC7530583 | biostudies-literature
UnknownData on the aquaporin gene expression differences among ρ0, clinically relevant radioresistant, and the parental cells of human cervical cancer and human tongue squamous cell carcinoma.
Not available
S-EPMC6116339 | biostudies-literature
UnknownLipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA.
Not available
S-EPMC6726706 | biostudies-literature
UnknownBone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.
Not available
S-EPMC3060401 | biostudies-literature
TranscriptomicsComparison of transcriptional profiling between insecticide-resistant (SP) and -susceptible (SMK) strains of Aedes aegypti
Aedes aegypti SP strain vs. SMK strain. Aedes aegypti is the major vector of yellow fever and dengue/dengue hemorrhagic fever. Starting with a population collected from Singapore, we established a pyrethroid-resistant A. aegypti strain (SP) and investigated three major possible mechanisms of insecti...
ORGANISM(S): Aedes aegypti 
2014-01-01 | E-GEOD-50069 | biostudies-arrayexpress
TranscriptomicsBone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
Carcinoma-associated fibroblasts (CAFs) that express ?-smooth-muscle-actin (?SMA+) contribute to cancer progression, but their precise origin and role in tumorigenesis is not established. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-23548 | biostudies-arrayexpress
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