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Transcriptomics22RV1 prostate cancer cell line transfected with SPINK1 siRNA vs control siRNA
ETS gene fusions have been characterized in a majority of prostate cancers, however key molecular alterations in ETS negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier-expression exclusively in a subset of ETS rearrangement negative cancers (~...
ORGANISM(S): Homo sapiens 
2008-06-10 | E-GEOD-11132 | biostudies-arrayexpress
TranscriptomicsIntegrative Molecular Concepts Modeling of Prostate Cancer Progression
Using laser capture microdissection to isolate over 100 specific cell populations, we report the profiling of prostate cancer progression from benign epithelium to metastatic disease. By analyzing these expression signatures in the context of over 15,000 â??molecular conceptsâ??, or sets of biologic...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-6099 | biostudies-arrayexpress
TranscriptomicsProfiling of RWPE cells stably over-expressing ETV1
RWPE benign prostatic epithelial cells were infected with a lentivirus expressing ETV1 or GUS (control), and stable clones were isolated by puromycin selection. ETV1 over-expression, recapitulating ETS gene rearrangements observed in vivo, confers invasiveness in the benign prostate cell line RWPE. ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-7701 | biostudies-arrayexpress
TranscriptomicsComparison of the prostate cancer cell line LNCaP and its androgen insensitive derivative C4-2B
LNCaP and its androgen insensitive derivative were profiled in order to identify genes differentially expressed during the conversion to androgen insensitivity. This experiment was performed due to the presence of an ins(7;14) localizing the entire ETV1 locus to chr 14 in LNCaP and C4-2B prostate ca...
ORGANISM(S): Homo sapiens 
2007-08-07 | E-GEOD-7702 | biostudies-arrayexpress
TranscriptomicsThe Mutational Landscape of Lethal Castrate Resistant Prostate Cancer
Characterization of the prostate cancer transcriptome and genome has identified chromosomal rearrangements and copy number gains/losses, including ETS gene fusions, PTEN loss and androgen receptor (AR) amplification, that drive prostate cancer development and progression to lethal, metastatic castra...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35988 | biostudies-arrayexpress
UnknownTargeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.
Not available
S-EPMC6075827 | biostudies-literature
TranscriptomicsTranscription profiling by array of human benign prostate, primary and metastatic prostate cancer samples to reveal signatures of metastatic progression
An integrative analysis of this compendium of proteomic alterations and transcriptomic data was performed revealing only 48-64% concordance between protein and transcript levels. Importantly, differential proteomic alterations between metastatic and clinically localized prostate cancer that mapped c...
ORGANISM(S): Homo sapiens 
2005-09-20 | E-GEOD-3325 | biostudies-arrayexpress
TranscriptomicsThe tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma
Rap1GAP is a critical tumor suppressor gene that is down-regulated in multiple aggressive cancers such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer. However, the mechanistic basis of rap1GAP down-regulation in cancers is poorly understood. By employing an integrative appr...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-28501 | biostudies-arrayexpress
GenomicsDiscovery of Non-ETS Gene Fusions in Human Prostate Cancer using Next Generation RNA Sequencing

Half of prostate cancers harbor gene fusions between TMPRSS2 and members of the ETS transcription factor family. To date little is known about the presence of non-ETS fusion events in prostate cancer. We employed next-generation transcriptome sequencing (RNA-Seq) in order to e...

phs000310.v1.p1 | EGA
UnknownAerosol precautions and airway complications: a national prospective multicentre cohort study.
Not available
S-EPMC10087829 | biostudies-literature
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