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TranscriptomicsGamma-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiation
CD34+ HPC cells were retrovirally transduced with either control PINCO-GFP or PINCO Gamma-Catenin-GFP and analysed for Affymetrix mRNA expression. Gamma-Catenin and control matched transduced cells were also cultured until day 6 and were fractionated into the main progenitor groups for Affymetrix m...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-MEXP-3810 | biostudies-arrayexpress
ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
2024-10-15 | PXD056836 |
UnknownFamotidine increases cellular phospho-tyrosine levels.
Not available
S-EPMC11490372 | biostudies-literature
TranscriptomicsTranscriptome profiling of quiescent and cytokine induced normal human haematopoietic CD34+ HSPCs, and AML blast cells
Control group is an essential part of the research design which provide a baseline by elimating variables, bias and other factors that skew the data. Human CD34+ cells are generally used as controls to study myeloid malignancies. This study determines whether fresh or short term cytokine induced CD3...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-MTAB-3328 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal progenitor cells mutated for RUNX1-RUNX1 during myeloid and erythroid development to identify genes disregulated by RUNX1-RUNX1
In order to identify genes dysregulated by the aberrant transcriptional activity of RUNX1-RUNX1T1, we used microarrays to determine the effect of this mutation on gene expression during myeloid and erythroid development of normal human progenitor cells.
ORGANISM(S): Homo sapiens 
2007-10-01 | E-MEXP-583 | biostudies-arrayexpress
TranscriptomicsIntegrated nuclear proteomics and transcriptomics identifies new high frequency dysregulated targets in acute myeloid leukemia
Acute myeloid leukemia (AML) is characterized by developmental arrest which is thought to arise from transcriptional dysregulation of myeloid development programs. Here, we have analyzed the transcriptome of AML blasts in comparison with normal human CD34+ cells using the HTA 2.0 gene chip. We have ...
ORGANISM(S): Homo sapiens 
2019-10-02 | E-MTAB-3873 | biostudies-arrayexpress
UnknownPTPN23-dependent ESCRT machinery functions as a cell death checkpoint.
Not available
S-EPMC11604704 | biostudies-literature
UnknownManipulating PTPRD function with ectodomain antibodies.
Not available
S-EPMC10546974 | biostudies-literature
UnknownA potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.
Not available
S-EPMC5798283 | biostudies-literature
UnknownHarnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.
Not available
S-EPMC5773487 | biostudies-literature
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