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ProteomicsSecretome from TXNIP knockout human colorectal cell line (DLD1)
Chemotherapy, the standard of care treatment for cancer patients with advanced disease, has been increasingly recognised to activate host immune responses to produce durable outcomes. Here, in colorectal adenocarcinoma (CRC) we identify oxaliplatin-induced Thioredoxin Interacting Protein (TXNIP), a ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-12 | PXD051666 | Pride
Human Txnip Colorectal Secreted 
UnknownSpatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface.
Not available
S-EPMC10113393 | biostudies-literature
MetabolomicsCadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes
Obesity is considered as a major public health concern with strong economic and social burdens. Exposure to pollutants such as heavy metals can contribute to the development of obesity and its associated metabolic disorders, including type 2 diabetes and cardiovascular diseases. Adipose tissue is an...
2023-06-29 | MTBLS4128 | MetaboLights
MetabolomicsArsenic induces metabolome remodeling in mature human adipocytes
Human lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the deve...
2025-05-23 | MTBLS8808 | MetaboLights
ProteomicsThe Role of Microtubules in the Trafficking of Ectopic ATP Synthase
Adenosine triphosphate (ATP) synthase is located on the inner membrane of mitochondria which generate ATP for various cellular processes. Our previous studies showed that ATP synthases existed on plasma membrane of several types of cancer cells, which was defined as ectopic ATP synthase. However, th...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD006791 | Pride
Ectopic atp synthases  proteomic analysis  the trafficking of mitochondria  microtubule  kif5b  drp1 
ProteomicsTrafficking of Ectopic ATP Synthase via Mitochondrial Fission
Ectopic ATP synthase is a functional onco-protein increases cell proliferation when transported to plasma membrane of cancer cells. Our previous study performed large scale gene silencing screening indicated ER and mitochondrial transport pathways may lead to ectopic ATP synthase expression. Silenci...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD007036 | Pride
Ectopic atp synthases  proteome  protein trafficking  mitochondrial fission  image analysis 
UnknownA computational framework for complex disease stratification from multiple large-scale datasets.
Not available
S-EPMC5975674 | biostudies-literature
UnknownThe MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas
Not available
S-SCDT-10_1038-S44321-024-00105-2 | biostudies-other
ProteomicsExercise plasma boosts memory and dampens brain inflammation via clusterin
Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects....
ORGANISM(S): Mus musculus (Mouse) 
2021-12-22 | PXD027406 | Pride
Proteomics Mouse Plasma 
ProteomicsExercise plasma dampens brain inflammation via clusterin and boosts memory
Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects....
ORGANISM(S): Mus musculus (Mouse) 
2021-12-22 | PXD022262 | Pride
Lc-msms Mouse Plasma 
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