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TranscriptomicsVolumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression
Dental decay induces dental pulp’s responses, which are still unclear. Firstly, we performed a complete volumetric imaging. Samples from healthy and diseased teeth were collected, processed into thick sections, transparized, immunolabeled, and imaged. Secondly, we performed single-cell RNA sequencin...
ORGANISM(S): Homo sapiens 
2025-11-01 | E-MTAB-14896 | biostudies-arrayexpress
TranscriptomicsEffects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ
The tooth is derived from both the ectoderm and the neural crest (ectomesenchyme). It is often used as a model for studies of the basic mechanisms of organ development, including differentiation, cellular interaction, morphogenesis, and mineralization of extracellular matrices. In mouse, tooth devel...
ORGANISM(S): Mus musculus 
2011-08-31 | E-MTAB-357 | biostudies-arrayexpress
ProteomicsTooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles
Tooth decay, also known as dental caries, is a prevalent oral health problem that significantly reduces an individual's quality of life; however, it can be effectively managed through restorative treatments. The condition primarily affects the enamel and dentin structures and can be treated before i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD064565 | Pride
Dental caries Senescence Tooth decay Dpsc 
TranscriptomicsTranscription profiling of mouse incisor tooth germ to associate changes in levels of mRNAs with development of enamel structure
The tooth is a convenient experimental model for the study of the basic mechanisms of organ development, including differentiation, cellular interaction, morphogenesis, and production and mineralization of extracellular matrices. The rodent incisor teeth grow continuously and exhibit all stages of t...
ORGANISM(S): Mus musculus 
2010-10-01 | E-MTAB-149 | biostudies-arrayexpress
ProteomicsMetaproteomic profiling of saliva in subjects with periodontitis, dental caries and orally healthy controls
The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. Thus, the purpose of the present investigation was to compare metaproteomic profiles of saliva in oral health and disease. Stimulated saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080763 | MassIVE
TranscriptomicsMolecular consequences of Dlx3 deletion in mouse enamel organ as determined by RNASeq analysis
DLX3 is a homeodomain transcription factor involved in ameloblast differentiation and enamel formation. Mutations in DLX3 in human lead to defects in enamel. However, the downstream targets of Dlx3 transcriptional activity in the enamel organ have not been identified yet. In this study, we compared ...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-57984 | biostudies-arrayexpress
GenomicsTopical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
PRJNA438685 | ENA
UnknownCanadian Professional Association Resources on Diet and Tooth Decay: Website Content Analysis.
Not available
S-EPMC12818494 | biostudies-literature
UnknownAnalysis of Race and Ethnicity, Socioeconomic Factors, and Tooth Decay Among US Children.
Not available
S-EPMC10273024 | biostudies-literature
ProteomicsUltra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
The oral cavity is home to one of the most diverse microbial community of the human body and a major entry portal for pathogens. Its homeostasis is maintained by saliva, which fulfills key functions including lubrication of food, predigesting and bacterial defense. Consequently, disruptions in saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080862 | MassIVE
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