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MetabolomicsTargeted plasma metabolomics combined with machine learning for the diagnosis of acute SARS-CoV-2

The routine clinical diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely restricted to real-time reverse transcription polymerase chain reaction (RT-qPCR), and tests that detect SARS-CoV-2 nucleocapsid antigen. Given the diagnostic delay and suboptimal sensitivity...

2024-08-26 | MTBLS6739 | MetaboLights
ProteomicsAnalysis of epididymal sperm maturation by top-down mass spectrometry
Spermatozoa Top-down analyses of different epididymal regions to identify endogenous biomolecules.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2014-12-16 | PXD001303 | Pride
Boar Epididymal spermatozoa Top-down 
ProteomicsDevelopment of a top-down MS assay for specific identification of human periostin isoforms
Periostin is a matricellular protein encoded by the POSTN gene that is alternatively spliced to produce ten different isoforms of periostin with a molecular weight ranging from 78 to 91 kDa. Periostin is known to promote fibrillogenesis, organize the extracellular matrix, and bind integrin-receptors...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-06-11 | PXD045560 | Pride
Alternative splicing Top down ms Periostin Proteoforms 
ProteomicsStreptococcal S protein is a coordinator of cell wall repair and defense against host antimicrobials
Pathogenic bacteria have acquired the ability to resist antibacterial defense mechanisms of the host. Streptococci are common in animal microbiota and include opportunistic pathogens like Group A Streptococcus (GAS) and Streptococcus pneumoniae (pneumococcus). While the conserved streptococcal S pro...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-06-08 | PXD055534 | Pride
S-protein Cell wall repair Streptococcus pneumoniae Penicillin-binding protein 
UnknownPartial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy.
Not available
S-EPMC7306449 | biostudies-literature
UnknownPinpointing top inhibitors for GSK3β from pool of indirubin derivatives using rigorous computational workflow and their validation using molecular dynamics (MD) simulations.
Not available
S-EPMC10761884 | biostudies-literature
ModelsConradie2010_RPControl_CellCycle
This model is from the article: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex. Conradie R, Bruggeman FJ, Ciliberto A, Csikász-Nagy A, Novák B, Westerhoff HV, Snoep JL FEBS J.2010 Jan; 277(2): 357-67 20015233, ...
2024-09-02 | BIOMD0000000265 | BioModels
UnknownTop-down facilitation of visual recognition.
Not available
S-EPMC1326160 | biostudies-literature
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
UnknownIsotopic Depletion Increases the Spatial Resolution of FPOP Top-Down Mass Spectrometry Analysis.
Not available
S-EPMC10831798 | biostudies-literature
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