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MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
TranscriptomicsTopoisomerase function in E. coli replication fork movement
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays. We used DNA microarrays of the Escherichia coli genome to trace the progression of chromosomal replication forks in synchronized cells. We found that both DNA gyrase and topoisomerase IV (topo IV) prom...
ORGANISM(S): Escherichia coli 
2001-07-30 | E-GEOD-8 | biostudies-arrayexpress
MetabolomicsControl of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST001658 | MetabolomicsWorkbench
TranscriptomicsTop3M-NM-2 is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation
Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3M-NM-2 (Top3M-NM-2) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein deficient in Fragile X syndrome and know...
ORGANISM(S): Homo sapiens 
2013-08-04 | E-GEOD-47502 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hela cells treated with the topoisomerase poison camptothecin
Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. The response of tumor cells to the unusual form of DNA damage caused by topoisomerase poisons such as camptothecin (CPT) is poorly understood, and knowledge regarding which drugs can be effecti...
ORGANISM(S): Homo sapiens 
2007-07-29 | E-GEOD-1417 | biostudies-arrayexpress
TranscriptomicsMapping of genome-wide action sites of topoisomerase IIbeta by a functional ChIP-chip technique (eTIP-tiling array)
DNA topoisomerase II (topo II) catalyzes a strand passage reaction in that one duplex is passed through a transient brake in another. Completion of late stages of neuronal development depends on the presence of active isoform (topo IIbeta). We identified topo IIbeta action sites on 7 selected genomi...
ORGANISM(S): Rattus norvegicus 
2010-05-15 | E-GEOD-13145 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors
Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cel...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23677 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brains of E14.5, E16.5 and E18.5 Top2b+/+ and top2b-/- embryos to study the role of DNA Topoisomerase IIbeta in gene expression
Mice lacking topoisomerase IIbeta (Top IIbeta) are known to exhibit a perinatal death phenotype. In the current study, transcription profiles of the brains of wild type and top2beta knockout mouse embryos were generated. Surprisingly, only a small number (1-4%) of genes were affected in top2beta kno...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5458 | biostudies-arrayexpress
TranscriptomicsCo-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43526 | biostudies-arrayexpress
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