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MetabolomicsMetabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control

Cells maintain metabolite homeostasis (metabolostasis) by buffering fluctuations in metabolite levels, yet the limits of this buffering and the mechanisms underlying metabolic toxicity remain poorly understood. To study this, we systematically overfed metabolites in Saccharomyces cerevisiae and q...

2026-09-29 | MTBLS12080 | MetaboLights
MetabolomicsSingle Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma
Not available
ORGANISM(S): Homo sapiens 
ST002203 | MetabolomicsWorkbench
GenomicsTopology regulates cell differentiation in situ
Topology regulates cell differentiation in situ
PRJNA1156072 | ENA
ProteomicsMass spectrometric analysis of membrane protein topology
Here we made an attempt to obtain partial structural information on the topology of multispan integral membrane proteins of yeast by isolating organellar membranes, removing peripheral membrane proteins at pH 11.5 and introducing chemical crosslinks between vicinal amino acids either using homo- or ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-10-11 | PXD006707 | Pride
Bs3 Plink Multispan proteins Edc Transmembrane domains 
GenomicAltered topology drives oncogenic programs in SDH-deficient GIST

Metabolic lesions with pleiotropic effects on epigenetic regulation and other cellular processes are widely implicated in cancer, yet their oncogenic mechanisms remain poorly understood. Succinate dehydrogenase (SDH) deficiency causes a subset of gastrointestinal stromal tumors (GISTs) with DNA h...

phs001906 | dbGaP
UnknownRational Design of Chitin Deacetylase Inhibitors for Sustainable Agricultural Use Based on Molecular Topology.
Not available
S-EPMC10389753 | biostudies-literature
UnknownMolecular Topology QSAR Strategy for Crop Protection: New Natural Fungicides with Chitin Inhibitory Activity.
Not available
S-EPMC7364431 | biostudies-literature
GenomicsAltered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs
PRJNA420090 | ENA
UnknownHow Molecular Topology Can Help in Amyotrophic Lateral Sclerosis (ALS) Drug Development: A Revolutionary Paradigm for a Merciless Disease.
Not available
S-EPMC8781553 | biostudies-literature
ProteomicsMulti-dimensional native proteomics technology for protein complex identification and topology characterization (Mud-NatPIT)
Here, we demonstrate a pilot development of multi-dimensional native proteomics technology for protein complex identification and topology characterization (Mud-NatPIT) in complex biological samples via coupling native size exclusion chromatography (SEC), online native capillary electrophoresis-mass...
ORGANISM(S): Escherichia coli 
2026-08-04 | PXD069439 | Pride
Capillary electrophoresis-mass spectrometry Protein complex identification Native proteomics Topology characterization Surface-induced dissociation 
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