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The lack of standardized protocols for isolating extracellular vesicles (EVs), particularly from biobank-stored plasma, poses a substantial limitation for the study of biomarkers. Combining current isolation methods could enhance the specificity and purity of EVs isolation for their further use in d...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD049342 | Pride
Critical limb threatening ischemia (CLTI), the most severe manifestation of peripheral artery disease, results from the chronic blockade of peripheral vessels, usually induced by atherosclerosis. CLTI patients suffer from high risk of amputation of the lower extremities and elevated mortality rates,...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD046843 | Pride
BACKGROUND. Atherosclerosis disease results from sustained lipid accumulation within the arterial walls and subsequent chronic inflammatory response, being the major responsible of adverse cardiovascular events with high mortality rates worldwide. An early identification of patients at risk of ather...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD049351 | Pride
Totipotent cells that resemble 2-cell stage embryos (2C-like cells) can arise with a very low frequency in ES cell cultures. Here we show that totipotent-like cells can be induced in vitro through the down-regulation of the chromatin assembly activity of CAF-1. Endogenous retroviruses and 2-cell sta...
ORGANISM(S): Mus musculus 
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