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The brain microenvironment imposes a particularly intense selective pressure on metastasis initiating cells, but successful metastasis bypass this control through mechanisms that are poorly understood. Reactive astrocytes are key components of this microenvironment, as they have been observed to con...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-16 | PXD008956 | Pride
Exclusion of cancer patients with brain metastases from clinical trials is a major cause of the limited therapeutic options available for secondary brain tumors. Here, we report a novel drug-screening platform (METPlatform) based on organotypic cultures that allows identifying anti-metastatic compou...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD020092 | Pride
Vestibular Schwannomas are benign neoplasms that arise from the vestibular nerve. The hallmark of these tumors is the biallelic inactivation of NF2. Transcriptomic alterations, such as the Nrg1/ErbB2 pathway, have been described in Schwannomas. Here, we have performed a whole transcriptomic analysis...
ORGANISM(S): Homo sapiens 
Ubiquitination controls most cellular processes, and its deregulation is associated to many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with ubiquitin E3 ligase activity and important functions in genome integrity. However, Nse1-dependent ubiquitin targets remain large...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-05 | PXD028669 | Pride
Mass Spectrometry analysis of the interactome of the oncoprotein NUP98-HOXA9
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD001828 | Pride
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