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ProteomicsReversible oxidative signaling in Chlamydomonas following nitrogen deprivation
As global temperatures climb to historic highs, the far-reaching effects of climate change have impacted agricultural nutrient availability. This has extended to low latitude oceans, where a deficit in both nitrogen and phosphorus stores has led to dramatic decreases in carbon sequestration in ocean...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-06-28 | PXD019491 | Pride
Oxidation Ptm Lcms Signaling Chlamydomonas 
ProteomicsIntegrated Dissection of Cysteine Oxidative Modification Proteome During Cardiac Hypertrophy
Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development. However, integrated dissection of multiple types of cysteine oxidation proteome in cardiac hypertrophy is currently missing. Here we developed a novel discovery platform encompassing ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-29 | PXD010336 | Pride
Mouse Cardiac hypertrophy Heart Biotin switch Dimethyl labeling Cysteine oxidation Reversible cysteine oxidation Cysteine sulfinylation Cysteine sulfonylation Quantitative proteomics 
ProteomicsChemical inhibition of the target of rapamycin kinase in Chlamydomonas reinhardtii leads to rapid cysteine oxidation and sustained physiological changes.
The target of rapamycin (TOR) kinase is a key metabolic regulator with a role in diverse processes, including nutritional sensing, protein translation, and autophagy. In the green alga Chlamydomonas reinhardtii, TOR maintains these responsibilities and is additionally linked to the regulation of inc...
ORGANISM(S): Chlamydomonas reinhardtii 
2019-10-04 | PXD014819 | Pride
Azd8055 Global proteomics Chlamydomonas reinhardtii Target of rapamycin Reversible cysteine oxidation 
ProteomicsGlobal proteomic effects of rapidly reversible electrophiles
Study the total protein levels following treatment with rapidly reversible small molecules
ORGANISM(S): Homo sapiens (Human) 
2024-06-08 | PXD050274 | Pride
Human jurkat reversible electrophile small molecules 
ProteomicsA chemoproteomics method for direct and comprehensive characterization of cysteine reversible oxidation
Cysteine oxidation is a series of protein modifications caused by reactive oxygen species (ROS) in cells and can regulate protein functions and cellular activities. Comprehensive and site-specific characterization of the cysteine oxidation is critical for understanding the role of ROS regulating cel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-20 | MSV000093703 | MassIVE
UnknownReversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes.
Not available
S-EPMC7139892 | biostudies-literature
ProteomicsOxSWATH applied to the redox characterization of secretomes under oxidative stress conditions
Most of the redox proteomics strategies are focused on the identification and relative quantification of cysteine oxidation changes without considering the variation in the total levels of the proteins. However, the regulation of protein synthesis and protein degradation are also associated with man...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD006802 | Pride
Redoxomics  cysteine oxidation  swath-ms  differential alkylation  secretome  dj-1 
UnknownQuantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model.
Not available
S-EPMC3045014 | biostudies-literature
ProteomicsIntegrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles
Silver nanoparticles (AgNPs) are widely used nanomaterials in both commercial and clinical biomedical applications, but the molecular mechanisms underlying their activity remain elusive. In this work we profiled proteomics and redox proteomics changes induced by AgNPs in two lung cancer cell lines:...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD021493 | Pride
Silver nanoparticles Mitochondria Lung Reversible protein oxidation Proteomics 
ProteomicsMetabolic shift underlies recovery in reversible infantile respiratory chain deficiency
Reversible infantile respiratory chain deficiency (RIRCD) is a rare mitochondrial myopathy leading to severe metabolic disturbances in infants, which recover spontaneously after 6 months of age. RIRCD is associated with the homoplasmic m.14674T>C mitochondrial DNA mutation, however only ~1/100 carri...
ORGANISM(S): Homo sapiens (Human) 
2020-10-13 | PXD020181 | Pride
Mitochondrial myopathy Digenic inheritance Reversible infantile respiratory chain deficiency Homoplasmic trna mutation 
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