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TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
ProteomicsOxygen Toxicity Causes Cyclic Damage by Destabilizing Specific Fe-S Cluster-Containing Protein Complexes
Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms remain largely unknown. Here, we systematically investigate the major cellular pathways affected by excess molecular oxygen. We find that hyperoxia destabilizes a specific subset of Fe-S cluster (ISC)-containi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-02-05 | MSV000091206 | MassIVE
ProteomicsOcular Inoculation of Toad Venom: Toxic Cataract and Proteomic Profiling
Purpose: To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen. Methods: A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD058328 | Pride
Toad venom  venom inoculation  toxic cataract  4d label-free quantitative proteomics  na+/k+-atpase 
GenomicsA non-toxic, abscisic acid-based anchor-away system for efficient nuclear depletion of budding yeast proteins
A non-toxic, abscisic acid-based anchor-away system for efficient nuclear depletion of budding yeast proteins
PRJNA629839 | ENA
TranscriptomicsToxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS. Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of ...
ORGANISM(S): Mus musculus 
2016-03-14 | E-GEOD-78730 | biostudies-arrayexpress
UnknownToxic anti-phage defense proteins inhibited by intragenic antitoxin proteins.
Not available
S-EPMC10327210 | biostudies-literature
UnknownToxic antiphage defense proteins inhibited by intragenic antitoxin proteins.
Not available
S-EPMC10400941 | biostudies-literature
TranscriptomicsTranscriptome profiling identified genes and pathways associated with arsenic toxicity and tolerance in Arabidopsis
Transcriptional profiling of arsenic-induced toxicity and tolerance in Arabidopsis plants of different ecotypes Arsenic (As) is a toxic metalloid found ubiquitously in the environment and has widely been known as an acute poison and carcinogen. As toxicity is a major factor leading to root growth i...
ORGANISM(S): Arabidopsis thaliana 
2011-11-26 | E-GEOD-31977 | biostudies-arrayexpress
Unknown"Non-Toxic" Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity.
Not available
S-EPMC4978960 | biostudies-literature
TranscriptomicsExpression data from yeast heterologously expressing alpha-ENaC, CFTR or Kir2.1 [CFTR]
Misfolded membrane proteins are retained in the endoplasmic reticulum (ER) and are subject to the ER associated degradation pathway, which clears the secretory pathway of potentially toxic species. While the transcriptional response to environmental stressors has been extensively studied, limited d...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-10 | E-GEOD-61244 | biostudies-arrayexpress
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