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ProteomicsToxicoproteomics reveals an effect of Clozapine on autophagy in human liver spheroids
Clozapine is an atypical antipsychotic drug for treatment-resistant schizophrenia. Its side effects, including liver enzyme abnormalities, experienced by many patients preclude a more common use as a first-line therapy of schizophrenia. Toxicoproteomics approaches have been demonstrated to effective...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD034257 | Pride
Drug-induced liver injury  data-independent acquisition  clozapine  proteomics  systems toxicologydrug-induced liver injury  data-independent acquisition  clozapine  proteomics  systems toxicology 
UnknownMechanism Investigation of Rifampicin-Induced Liver Injury Using Comparative Toxicoproteomics in Mice.
Not available
S-EPMC5535909 | biostudies-literature
ProteomicsToxicoproteomics of environmental mixtures in prostate diseases
These data are from the following 2 experiments: 1. normal prostate stromal cells (BHPRS1) treated with either 0.1 uM mono(2-ethylhexyl) phthalate (MEHP), 3 uM perfluorooctanesulfonic acid (PFOS), the mixture of MEHP+PFOS, or DMSO vehicle (0.06% v/v); n=3 each 2. metastatic prostate epithelial cells...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD014428 | Pride
Toxicoproteomics prostate benign stroma metastatic epithelium phthalate mehp perfluoroalkyl substance pfos 
UnknownIntegrative analysis of toxicometabolomics and toxicoproteomics data: new molecular insights into thiazolidinedione-induced cardiotoxicity.
Not available
S-EPMC11621136 | biostudies-literature
ProteomicsToxicoproteomics of HepG2 Reveals Translational Biomarkers of Paracetamol-Induced Liver Injury and Recovery
Drug-induced liver injury (DILI) is a leading cause of acute liver failure (ALF) and a major obstacle in drug development, reflecting the limited predictive value of animal models and lack of robust,mechanism-based biomarkers. Human in vitro systems, coupled with unbiased omics approaches, have emer...
ORGANISM(S): Homo sapiens (Human) 
2026-07-27 | PXD072667 | Pride
UnknownProteomic Signatures of the Zebrafish (Danio rerio) Embryo: Sensitivity and Specificity in Toxicity Assessment of Chemicals.
Not available
S-EPMC3200224 | biostudies-literature
UnknownToxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases.
Not available
S-EPMC10041651 | biostudies-literature
UnknownResponses of A549 human lung epithelial cells to cristobalite and α-quartz exposures assessed by toxicoproteomics and gene expression analysis.
Not available
S-EPMC5434822 | biostudies-literature
UnknownToxicoproteomics Disclose Pesticides as Downregulators of TNF-α, IL-1β and Estrogen Receptor Pathways in Breast Cancer Women Chronically Exposed.
Not available
S-EPMC7483484 | biostudies-literature
ProteomicsRifampicin-mouse liver proteomics
Tuberculosis is one of top causes of death among curable infectious diseases; it is an airborne infectious disease that kills 2 million people worldwide. Anti-tuberculosis drug-induced liver injury is the primary cause of drug-induced liver injury (DILI). Rifampicin is one of the most common anti-tu...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-10 | PXD006313 | Pride
Mouse liver Toxicoproteomics Tmt labeling Rifampicin 
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