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ProteomicsProteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin
Drug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive.
ORGANISM(S): Mycobacterium Smegmatis Str. Mc2 155 (ncbitaxon:246196) 
2019-03-18 | MSV000083589 | MassIVE
TranscriptomicsPhenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
In this study we have used the rifampicin selection as a tool to genetically improve the erythromycin producer Saccharopolyspora erythraea. Two rifampicin-resistant (rif) mutants, rif1 and rif6, have been characterized in more detail. With respect to the parental strain NRRL2338, rif1 (harboring the...
ORGANISM(S): Saccharopolyspora erythraea 
2009-04-12 | E-GEOD-12017 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Rifampicin-induced transcriptome response in rifampicin-resistant Mycobacterium tuberculosis
Tuberculosis (TB) is still a major life-threatening infectious disease, within which especially the rise of multidrug resistant TB (MDR-TB) is currently worrying. This study focuses on mechanisms of development of rifampicin resistance, since rifampicin seems to play an important role in the develop...
ORGANISM(S): Mycobacterium tuberculosis 
2013-04-21 | E-BUGS-139 | biostudies-arrayexpress
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome
This SuperSeries is composed of the following subset Series: GSE24186: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform] GSE24187: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix pla...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24188 | biostudies-arrayexpress
ProteomicsBacteria Sense the Antibiotic Rifampicin Through a Widespread Dual-Promoter Based Alarm System
Most antibiotics are natural compounds or their derivatives, and bacteria have evolved defensive mechanisms to resist them. Many of these mechanisms are still poorly understood or uknown. This study reveals that in Bacillus subtilis the transcription factor HelD increases resistance to rifampicin by...
ORGANISM(S): Bacillus subtilis 
2025-12-18 | PXD066046 | Pride
Rna polymerase  held  rifampicin 
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]
With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24187 | biostudies-arrayexpress
ProteomicsRifampicin-mouse liver proteomics
Tuberculosis is one of top causes of death among curable infectious diseases; it is an airborne infectious disease that kills 2 million people worldwide. Anti-tuberculosis drug-induced liver injury is the primary cause of drug-induced liver injury (DILI). Rifampicin is one of the most common anti-tu...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-10 | PXD006313 | Pride
Mouse liver Toxicoproteomics Tmt labeling Rifampicin 
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform]
With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24186 | biostudies-arrayexpress
ProteomicsBeyond Inhibition - Sub-lethal Rifampicin-induced molecular adaptations confer phenotypic drug tolerance in Mycobacteria
This study investigates how sub-lethal concentrations of rifampicin act as a signalling stimulus that induces phenotypic drug tolerance in mycobacteria. Using Mycobacterium smegmatis as a fast-growing model and validating findings in the attenuated Mycobacterium tuberculosis H37Ra strain, we examine...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Bacteria Mycobacterium tuberculosis H37Ra 
2026-06-08 | PXD075873 | Pride
TranscriptomicsBiological cost of rifampicin resistance in Helicobacter pylori
The present study was aimed at analyzing (i) the biological cost of RNA polymerase (rpoB) mutations conferring rifampin resistance on H.pylori, (ii) the relationship between the cost of rpoB mutations and the chromosomal mutaion, (iii) the relationship between the cost of rpoB mutations and the tra...
ORGANISM(S): Helicobacter pylori 26695 
2010-11-30 | E-GEOD-25333 | biostudies-arrayexpress
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