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ProteomicsGlobal and phosphoproteomics in control and TP53RK-deficient HT29 cells
We compared the global proteome and phosphoproteome between control and TP53RK-deficient HT29 cells using tandem mass tag (TMT) labeling for quantitative analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD061604 | Pride
Ht29 Tmt Tp53rk Cell line Lc-ms/ms 
GenomicsIdentifying TP53RK as a key regulator of colorectal cancer survival and a potential therapeutic target
This study identifies TP53RK as a key regulator of colorectal cancer (CRC) cell survival by stabilizing CDC7 for proper DNA replication. Its loss causes replication stress, apoptosis, and cell cycle arrest, making TP53RK a promising therapeutic target for CRC.
PRJEB86798 | ENA
UnknownTP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.
Not available
S-EPMC10477881 | biostudies-literature
UnknownIdentifying TP53RK as a key regulator of colorectal cancer survival and a potential therapeutic target.
Not available
S-EPMC12533122 | biostudies-literature
UnknownA familial case of Galloway-Mowat syndrome due to a novel TP53RK mutation: a case report.
Not available
S-EPMC6063015 | biostudies-literature
UnknownNovel TP53RK variants cause varied clinical features of Galloway-Mowat syndrome without nephrotic syndrome in three unrelated Chinese patients.
Not available
S-EPMC9977797 | biostudies-literature
UnknownIdentification of TP53RK-Binding Protein (TPRKB) Dependency in TP53-Deficient Cancers.
Not available
S-EPMC6679750 | biostudies-literature
UnknownMutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Not available
S-EPMC5819591 | biostudies-literature
UnknownNovel Epigenetic CREB-miR-630 Signaling Axis Regulates Radiosensitivity in Colorectal Cancer.
Not available
S-EPMC4532457 | biostudies-literature
UnknownSystematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library.
Not available
S-EPMC7476084 | biostudies-literature
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