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TranscriptomicsTranscription profiling by array of human trabecular meshwork cells to investigate the molecular mechanisms by which MYOC mutants cause glaucoma
Comparison of human trabecular meshwork transcriptomes of cells glaucoma-linked MYOC mutant Q368X
ORGANISM(S): Homo sapiens 
2012-10-06 | E-MEXP-3427 | biostudies-arrayexpress
TranscriptomicsConstitutively active RhoA (RhoAV14) expression and regulation of acqeous humor outflow dynamics
Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPa...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-9288 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human trabecular meshwork cultured cells, non-glaucomatous and POAG tissue
The goal of this study was to contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells, to that of control and primary open angle glaucoma (POAG) HTM tissues. Total RNA from cultured HTM cells and HTM tissue dissected from control and POAG anterior segments fix...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4316 | biostudies-arrayexpress
TranscriptomicsMYOC.WTvsNull
Comparison of human trabecular meshwork transcriptomes of cells overexpressing wild-type Myocilin
ORGANISM(S): Homo sapiens 
2012-10-06 | E-MEXP-3440 | biostudies-arrayexpress
TranscriptomicsMYOC.D380NvsNull
Comparison of human trabecular meshwork transcriptomes of cells overexpressing glaucoma-linked MYOC mutant D380N
ORGANISM(S): Homo sapiens 
2012-09-08 | E-MEXP-3434 | biostudies-arrayexpress
TranscriptomicsMYOC.R342KvsNull
Comparison of human trabecular meshwork transcriptomes of cells overexpressing glaucoma-linked MYOC mutant R342K
ORGANISM(S): Homo sapiens 
2012-09-08 | E-MEXP-3435 | biostudies-arrayexpress
TranscriptomicsMYOC.K423EvsNull
Comparison of human trabecular meshwork transcriptomes of cells overexpressing glaucoma-linked MYOC mutant K423E
ORGANISM(S): Homo sapiens 
2012-10-06 | E-MEXP-3439 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone
PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to ...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-6298 | biostudies-arrayexpress
TranscriptomicsDexamethasone induced gene expression changes in the human trabecular meshwork
One of the undesirable side effects of glucocorticoid use is the potential development of elevated intraocular pressure and glaucoma. The precise mechanisms through which steroid use induces ocular hypertension are unclear. The purpose of this study was to identify gene expression changes induced by...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37474 | biostudies-arrayexpress
TranscriptomicsEffects of dexamethasone for primary trabecular meshwork cell gene expression
To clarify the effects of dexamethasone treatment for primary trabecular meshwork cell gene expression, which may relates to the pathophysiology of glucocorticoid-induced glaucoma Three lots (lot #2584, 3423 and 4973) of primary culture human trabecular meshwork (TM) cells were purchased from ScienC...
ORGANISM(S): Homo sapiens 
2015-01-24 | E-GEOD-65240 | biostudies-arrayexpress
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