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TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
ProteomicsKinome profiling of venetoclax-resistant wild type and NRAS-G12C MOLM-14 cells
Despite efficacy of FLT3 and BCL2 inhibition in acute myeloid leukemia (AML), relapse limits survival. Mutation status and AML monocytic differentiation are implicated in resistance. On-treatment tumor evolution may select for genetically distinct clones or shifts in differentiation not resolvable ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD068585 | Pride
Venetoclax Gilteritinib Kinase Inhibitor Bead Aml 
TranscriptomicsGene expression profiling of in vitro matured bovine oocytes cultivated with or without cumulus cells.
Cumulus cells, surrounding the oocyte, play a key role in the acquisition of oocyte competence to be fertilized and to sustain early embryo development. Cumulus cells contribute to oocyte development by metabolizing energy substrates such as glutathione that may protect the oocyte from oxidative str...
ORGANISM(S): Bos taurus 
2011-08-16 | E-GEOD-31361 | biostudies-arrayexpress
TranscriptomicsCell Intrinsic role of Cox-2 in pancreatic cancer development
Cyclooxygenase-2 (COX-2) is upregulated in pancreatic ductal adenocarcinomas (PDAC). However, how COX-2 promotes PDAC development is unclear. While previous studies have evaluated the efficacy of COX-2 inhibition via the use of non steroidal anti-inflammatory drugs (NSAIDs) or the COX-2 inhibitor ce...
ORGANISM(S): Mus musculus 
2012-06-28 | E-GEOD-38988 | biostudies-arrayexpress
UnknownMeta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Not available
S-EPMC3354734 | biostudies-literature
UnknownDesign innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.
Not available
S-EPMC3481179 | biostudies-literature
Unknown2014 CUA Abstracts
Not available
S-EPMC4095672 | biostudies-literature
UnknownVariation in GIGYF2 is not associated with Parkinson disease.
Not available
S-EPMC2690967 | biostudies-literature
UnknownParkin dosage mutations have greater pathogenicity in familial PD than simple sequence mutations.
Not available
S-EPMC2715211 | biostudies-literature
UnknownMutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.
Not available
S-EPMC2677501 | biostudies-literature
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