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TranscriptomicsTranscription profiling of mouse adipose tissue of lipodystrophic aP2-nSREBP1c trangenic animals
Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old aP2-nSREBP1c transgenic males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ„¢ arrays,...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9130 | biostudies-arrayexpress
ProteomicsCorneal protome of trangenic TGFBI R124H mouse model
In this study we analysed the proteome of transforming growth factor β-induced protein (TGFBIp) R124H transgenic mouse corneas in an attempt to understand the disease mechanisms leading to the granular corneal dystrophy type 2. The transgenic mouse model was generated by insertion of human TGFBI cDN...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-10-20 | PXD012902 | Pride
Mouse Cornea Lc-ms/ms 
TranscriptomicsGene expression profiling of the AD11 anti-NGF transgenic mouse model of neurodegeneration at 1, 3, 6, 15 months of age
We characterized the gene expression profile of brain regions at different stages of the AlzheimerM-bM-^@M-^Ys like neurodegeneration in the anti-NGF AD11 trangenic mouse model. Total RNA was extracted from hippocampus, cortex and basal forebrain of postnatal day 30 (P30, 1 month), P90 (3 months), P...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-63617 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of CD45+ cells taken from the ear epidermis from K14E7 transgenic and wildtype C57/BL6 mice
Langerhans cells (LC) in skin help initiate the immune response to locally presented antigens. We performed high-resolution single-cell RNA-sequencing (scRNAseq) analysis for antigen presenting cells including LC in normal mouse skin, and in mouse skin expressing the human papillomavirus (HPV) 16 ...
ORGANISM(S): Mus musculus 
2021-10-15 | E-MTAB-8199 | biostudies-arrayexpress
TranscriptomicsThe role of TP63 fusion in mouse lymphomagenesis
Patients with lymphoma harboring TP63 rearrangements have aggressive clinical course and dismal prognosis with no target therapy available. Thus, there is an urgent need to elucidate the molecular mechanisms and to develop novel therapeutic options for these patients. We then generated a TBL1XR1::TP...
ORGANISM(S): Mus musculus 
2023-10-01 | GSE240201 | GEO
ProteomicsProteomics of Skin Proteins in Psoriasis
Herein we demonstrate the efficacy of an unbiased proteomics screening approach for studying protein expression changes in the KC-Tie2 psoriasis mouse model, identifying multiple protein expression changes in the mouse and validating these changes in human psoriasis. KC-Tie2 mouse skin samples (n=3...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-30 | PXD001387 | Pride
Psoriasis Trangenic mouse Lc-msms 
TranscriptomicsSox17-transgenic hematopoietic stem cell microarray
The transcription factor SOX17 is expressed by fetal, but not adult hematoipoietic stem cells (HSCs), and is required for the maintenance of fetal and neonatal, but not adult, HSCs. In the current study we show that ectopic expression of Sox17 in adult HSCs and transiently reconstituting multipotent...
ORGANISM(S): Mus musculus 
2011-07-14 | E-GEOD-30445 | biostudies-arrayexpress
TranscriptomicsOverexpression of splicing factor SRSF6 in mouse skin
Many biological processes involve post-transcriptional regulation of gene expression by alternative pre-mRNA splicing. Here, we show that an alternative splicing factor SRSF6 affects tissue homeostasis of the skin. In this dataset, we study effects on gene expression and alternative splicing upon SR...
ORGANISM(S): Mus musculus 
2014-01-19 | E-GEOD-52458 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
GenomicsThe role of TP63 fusion in mouse lymphomagenesis
The role of TP63 fusion in mouse lymphomagenesis
PRJNA1002796 | ENA
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