Sort   by:  
 Page size 
GenomicsCorepressors (NCoR and SMRT) as well as Coactivators are Recruited to Positively Regulated 1α,25-Dihydroxyvitamin D3-Responsive Genes
Transcription factors require coactivators and corepressors to modulate transcription in mammalian cells. The vitamin D receptor (VDR) utilizes coactivators and corepressors to gain tight control over the activity of a diverse set of genes that can regulate calcium transport, slow proliferation and...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-39277 | biostudies-arrayexpress
ProteomicsBS3 intermolecular crosslinking map of SAGA and SLIK (SAGA-like) transcription coactivators
The SAGA-like complex SLIK is a modified version of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. SLIK is formed through C-terminal truncation of the Spt7 SAGA subunit, causing loss of Spt8 that interacts with the TATA-binding protein. SLIK and SAGA are both coactivators of RNA polymerase II tr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-19 | PXD024640 | Pride
Dna-protein interaction Cryo-electron microscopy Histone deubiquitination Transcriptional coactivator Histone acetylation 
UnknownRho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts.
Not available
S-EPMC4018493 | biostudies-literature
TranscriptomicsTranscription profiling of wild type and PGC-1 alpha knockout mouse mature brown adipocytes treated with or without dibutyryl cAMP to investigate the specific role of PGC-1 coactivators in brown fat cells
To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat diffe...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiated brown adipocytes from wild type, PGC-1 alpha knockout, or PGC-1 alpha knockout and PGC-1 beta knockdown mice to investigate the roles of PGC-1 coactivators in brown fat differentiation.
Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lac...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5042 | biostudies-arrayexpress
UnknownThe transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Not available
S-EPMC3050627 | biostudies-literature
UnknownTranscription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.
Not available
S-EPMC3724885 | biostudies-literature
UnknownNuclear receptor coactivators: structural and functional biochemistry.
Not available
S-EPMC3647688 | biostudies-literature
UnknownAn acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function.
Not available
S-EPMC8668987 | biostudies-literature
UnknownControl of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.
Not available
S-EPMC548005 | biostudies-literature
Sort   by:  
 Page size