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TranscriptomicsTranscription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells
Genomic mapping of DNA replication origins (ORIs) in mammals provides a powerful means for understanding the regulatory complexity of our genome. Here we combine a genome-wide approach to identify preferential sites of DNA replication initiation at 0.4% of the mouse genome with detailed molecular an...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-15082 | biostudies-arrayexpress
GenomicsCcr4-Not complex reduces transcription efficiency in heterochromatin
Ccr4-Not complex reduces transcription efficiency in heterochromatin
PRJNA773101 | ENA
GenomicsAgeing-associated changes in transcription and splicing efficiency influence longevity
Ageing-associated changes in transcription and splicing efficiency influence longevity
PRJNA397980 | ENA
GenomicsTranscription analysis of different water use efficiency genotypes in soybean leaf
Transcription analysis of different water use efficiency genotypes in soybean leaf
PRJNA666440 | ENA
TranscriptomicsTranscriptional profiling of response to acute caloric restriction in liver and fat of pigs differing in feed efficiency
Residual feed intake (RFI) is a measure of feed efficiency, where low RFI denotes high feed efficiency. Caloric restriction (CR) is associated with feed efficiency in livestock species and to human health benefits such as longevity and cancer prevention. We have developed pig lines that differ in RF...
ORGANISM(S): Sus scrofa 
2010-01-10 | E-GEOD-18359 | biostudies-arrayexpress
TranscriptomicsRapid, high efficiency isolation of pancreatic ß-cells
The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed an exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional pancreatic ß-cells. By targeting the glucagon-like peptide-1 receptor, ß-cells were isolate...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-64508 | biostudies-arrayexpress
TranscriptomicsDIRECT CONVERSION OF FIBROBLASTS INTO FUNCTIONAL ASTROCYTES BY DEFINED TRANSCRIPTION FACTORS
Direct cell reprogramming has enabled the direct conversion of skin fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell lineage-specific transcription factors. This approach has substantial advantages since it is rapid and simple, generating the cell type of interest...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59018 | biostudies-arrayexpress
TranscriptomicsSelection for improved energy efficiency and drought tolerance in canola results in distinct transcriptome and epigenome changes [RNA-Seq]
Integrated breeding strategies are used to increase both the yield potential and stability of crops. Most of these approaches have a direct genetic basis. The utility of epigenetics in breeding to improve complex traits such as yield and stress tolerance is not clear. A better understanding of th...
ORGANISM(S): Brassica napus 
2015-06-28 | E-GEOD-65572 | biostudies-arrayexpress
GenomicsSelection for improved energy efficiency and drought tolerance in canola results in distinct transcriptome and epigenome changes [ChIP-Seq]
Integrated breeding strategies are used to increase both the yield potential and stability of crops. Most of these approaches have a direct genetic basis. The utility of epigenetics in breeding to improve complex traits such as yield and stress tolerance is not clear. A better understanding of th...
ORGANISM(S): Brassica napus 
2015-06-28 | E-GEOD-65571 | biostudies-arrayexpress
ProteomicsRECQL5 and transcription-coupled DNA repair complex coordinate to regulate transcription elongation
The RECQL5 helicase is crucial for maintaining genome stability and functions at the intersection of transcription, replication, and DNA repair. RECQL5 associates with RNA15 polymerase II (Pol II) to modulate transcription elongation, yet the underlying mechanism remains unclear. Here, we report cry...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD062042 | Pride
Recql5 Transcription Crosslinking 
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