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MetabolomicsRcrR: A Multifunctional Transcriptional Regulator Orchestrating the cariogenic virulence of Streptococcus mutans

We systematically investigated RcrR's contribution to cariogenic virulence using isogenic wild-type, DeltarcrR deletion mutant, and complemented strains. We assessed bacterial growth, biofilm architecture, acid tolerance, and H+-ATPase activity. To delineate the global regulatory network, we inte...

2026-08-06 | MTBLS15272 | MetaboLights
TranscriptomicsTranscription profiling of Neisseria meningitidis knock out mutant of snC transcriptional regulator compared to parent strains
Knock out mutant of asnC transcriptional regulator (NMB0573) in N. meningitidis MC58 compared to parent strains (capsule deletion mutant) grown in normal bacterial solid media plate conditions.
ORGANISM(S): Neisseria meningitidis 
2007-04-05 | E-MEXP-925 | biostudies-arrayexpress
TranscriptomicsThe Candida glabrata transcription factor Stb5p is a negative regulator of ATP-binding cassette transporters
The opportunistic yeast pathogen Candida glabrata is recognized for its ability to acquire resistance during prolonged treatment with azole antifungals. Resistance to azoles is largely mediated by the transcription factor PDR1, resulting in the upregulation of ATP-binding cassette (ABC) transporter ...
ORGANISM(S): Candida glabrata 
2013-03-11 | E-GEOD-37071 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe
At Schizosaccharomyces pombe centromeres, non-coding RNAs are transcribed by RNA polymerase II and processed by the RNAi machinery to direct heterochromatin formation. Mediator is a regulator of RNA polymerase II transcription and we here demonstrated that it also controls the levels of centromeric ...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-32310 | biostudies-arrayexpress
TranscriptomicsSarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis
Biofilm-associated infection by the leading nosocomial pathogen Staphylococcus epidermidis is a major problem for the public health system. Here we used an especially discriminatory, two-step screen to discover key biofilm factors. We identified the transcriptional regulator and SarA paralog SarZ as...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-25 | E-GEOD-8523 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of normal and ripening inhibitor (rin) mutant tomatoes during ripening
Ripening is an important stage of fruit development to determine its quality as a diet. A tomato (Solanum lycopersicum) MADS-box transcription factor, RIPENING INHIBITOR (RIN), has been believed to serve as a regulator of ripening lying upstream of ethylene-dependent and ethylene-independent pathway...
ORGANISM(S): Solanum lycopersicum 
2012-04-01 | E-GEOD-28564 | biostudies-arrayexpress
TranscriptomicsCharacterization of PlcRa, a new PlcR-like regulator involved in oxidative stress response and cysteine metabolism during early stationary phase in Bacillus cereus
PlcR, the major virulence transcriptional regulator in the Bacillus cereus group belongs to the RNPP quorum sensor family and is activated through interaction with the secreted heptapeptide PapR7 used as a signalling molecule. We identified using modeling analysis a structural homologue of PlcR, Plc...
ORGANISM(S): Bacillus cereus ATCC 14579 
2012-12-14 | E-GEOD-30514 | biostudies-arrayexpress
Models,MultiomicsCell Cycle Transcription by Coupled CDK and Network Oscillators
A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulating cell-cycle events. Genomic analyses of the localization and expression dynamics of transcription factor...
2681 | Cell Collective
TranscriptomicsZebrafish 27hpf embryos: hdac1 mutant (hi1618) vs sibling
Transcriptional profiling of hdac1 mutant zebrafish in comparison to their sibling embryos. Embryos resulting from a cross between heterozygous hdac1 mutant zebrafish (hi1618/+) where cultured together then mutants separated from the siblings one the basis of phenotype and RNA extracted from the tw...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26707 | biostudies-arrayexpress
TranscriptomicsGene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis
Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their re...
ORGANISM(S): Arabidopsis thaliana 
2015-02-03 | E-GEOD-62597 | biostudies-arrayexpress
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