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ProteomicsBRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation
Understanding the precise functions and relationship of BRD2 with other bromodomain and extraterminal motif (BET) proteins is central for the application of BET-specific and pan inhibitors. Here, we used acute protein degradation and quantitative genomic and proteomic approaches to investigate the p...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD030774 | Pride
Brd2 Transcriptional initiation and elongation Cell differentiation Brd3 
Transcriptomics4sUDRB-seq: measuring transcription elongation and initiation genomewide
A new method to measure elongation and intitiation rates Reversal inhibition of transcription with DRB and tagging newly transcribed RNA with 4-thiouridine (4sU)
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-57116 | biostudies-arrayexpress
TranscriptomicsMultiple roles for LEC in initiation and elongation phases of snRNA gene transcription
The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to unique aspects of their promoter structure, selectivity for either RNA Polymerase (Pol) II or III and a unique mechanism of termination that is tightly linked with the prom...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-47938 | biostudies-arrayexpress
TranscriptomicsStably-paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor Triptolide
Transcription by RNA Polymerase II (Pol II) in metazoan is regulated in several steps, including preinitiation complex (PIC) formation, initiation, Pol II escape, productive elongation, cotranscriptional RNA-processing and termination. Genome-wide studies have demonstrated that the phenomenon of ...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-63314 | biostudies-arrayexpress
GenomicsCK2 regulates transcriptional elongation
CK2 binds to actively transcribed regions in the genome and regulates transcriptional elongation. Identification of genome-wide binding sites of CK2?, and examination of the effect of Pol II binding upon CK2 inhibition in LNCaP cells
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-58607 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression of wild-type and Li2 mutant fibers during initiation or early elongation
Gene expression profiling of wild-type and Li2 mutants were investigated with Affymetrix cotton Genome Array focused primarily on time-points related to fiber elongation, more specifically, 8 and 12 days post anthesis (DPA). These time points typically represent peak rates of elongation and the begi...
ORGANISM(S): Gossypium hirsutum 
2012-07-05 | E-MEXP-3306 | biostudies-arrayexpress
TranscriptomicsA Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory
LSD1n regulates transcriptional elongation by removing H4K20 methylation. Identification of genome-wide binding sites of LSD1, and examination of the histone modifications upon LSD1n deletion in primary cortical neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-63271 | biostudies-arrayexpress
GenomicsCompromised Transcriptional Elongation Stimulates Initiation in Human Cells [4sU-DRB-seq]
Compromised Transcriptional Elongation Stimulates Initiation in Human Cells [4sU-DRB-seq]
PRJNA1253711 | ENA
GenomicsDOT1L complex regulates transcriptional initiation in human cells
DOT1L complex regulates transcriptional initiation in human cells
PRJNA677967 | ENA
GenomicsMultiple roles for LEC in initiation and elongation phases of snRNA gene transcription
Multiple roles for LEC in initiation and elongation phases of snRNA gene transcription
PRJNA208481 | ENA
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