Brd2 - OmicsDI

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Brd2 regulates gene expression and alternative splicing.

We analyzed a role of Brd2 protein in transcription and alternative splicing. 289 genes change alternative splicing after Brd2 knockdown and 1459 genes alter gene expression compared to cells treated with negative control siRNA. 6 samples (3 independent samples of cells treated with Brd2 siRNA, 3 sa...

ORGANISM(S): Homo sapiens

2013-12-03 | E-GEOD-39937 | biostudies-arrayexpress

BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation

Understanding the precise functions and relationship of BRD2 with other bromodomain and extraterminal motif (BET) proteins is central for the application of BET-specific and pan inhibitors. Here, we used acute protein degradation and quantitative genomic and proteomic approaches to investigate the p...

ORGANISM(S): Mus musculus (Mouse)

2024-05-22 | PXD030774 | Pride

Bromodomain-containing protein 2 (BRD2) interactome in ES cells

Identification of Bromodomain-containing protein 2 (BRD2) interaction partners using liquid-chromatography based mass spectrometry in murine embryonic stem cells (ESC), using BRD2 endogenously tagged with a mAID-V5 tag.

ORGANISM(S): Mus musculus (Mouse)

2026-04-22 | PXD072982 | Pride

Lc-msms Brd2 Esc cells Bromodomain Interactome

H2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [ChIP-seq]

Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...

ORGANISM(S): Mus musculus

2016-01-21 | E-GEOD-53206 | biostudies-arrayexpress

H2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [RNA-seq]

ORGANISM(S): Mus musculus

2016-01-21 | E-GEOD-53207 | biostudies-arrayexpress

Haploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in male mouse striatum

Our previous work confirmed that Brd2+/- mouse presents the sex specific characteristics of juvenile myoclonic epilepsy, a subsyndrome of idiopathic generalized epilepsy. Here, we investigated the role of Brd2 gene in modulating the genomic fabrics responsible for the glutamatergic, GABAergic, dopam...

ORGANISM(S): Mus musculus

2015-09-01 | E-GEOD-72562 | biostudies-arrayexpress

Transcription profiling of mouse BRD2-mediated lymphomas

The dual bromodomain protein Brd2 is closely related to the basal transcription factor TAFII250, which is essential for cyclin A transactivation and mammalian cell cycle progression. In transgenic mice, constitutive lymphoid expression of Brd2 causes a malignancy most similar to human diffuse large ...

ORGANISM(S): Mus musculus

2008-06-14 | E-GEOD-6136 | biostudies-arrayexpress

Haploinsufficiency in bromodomain containing 2 (Brd2) gene remodels synaptic transmission in female mouse striatum in a sex-specific manner

Our previous work showed that Brd2+/- mouse models the sex specific characteristics of juvenile myoclonic epilepsy, a subsyndrome of idiopathic generalized epilepsy. Here, we investigated a role of Brd2 gene in modulating the genomic fabrics responsible for the glutamatergic, GABAergic, dopaminergic...

ORGANISM(S): Mus musculus

2015-09-01 | E-GEOD-72563 | biostudies-arrayexpress

BRD2 CUT & RUN in Calu-3 cells

PRJNA758691 | ENA

Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics

PRJNA1134240 | ENA

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