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TranscriptomicsRegulation of PTSBio by transcriptional repressor NigR
In this study we analyzed the transcriptional regulation of the operon (OBio) encoding the PTSBio and showed that it was repressed by NigR, a LacI-like transcriptional regulator. To elucidate the role of NigR in regulation of S. mutans carbohydrate transporters we performed full genome expression mi...
ORGANISM(S): Streptococcus mutans UA159 
2015-06-22 | E-GEOD-63213 | biostudies-arrayexpress
TranscriptomicsThe metalloregulatory site in Streptococcus pneumoniae AdcR, a zinc-activated MarR-family repressor
Streptococcus pneumoniae D39 AdcR (adhesion competence repressor) is the first metal-sensing member of the MarR (multiple antibiotic resistance repressor) family to be characterized. Expression profiling of a ∆adcR strain grown in liquid culture under microaerobic conditions revealed that transcr...
ORGANISM(S): Streptococcus pneumoniae 
2010-10-01 | E-GEOD-21506 | biostudies-arrayexpress
TranscriptomicsComplex regulation of the PEP carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
DNA affinity chromatography with the promoter region of the Corynebacterium glutamicum pck gene, encoding phosphoenolpyruvate carboxykinase (PEPCk), led to the isolation of four transcriptional regulators, i.e., RamA, GntR1, GntR2 and IolR. Determination of the PEPCk activity of the deletion mutant...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2013-07-29 | E-GEOD-44812 | biostudies-arrayexpress
ProteomicsDefining the interactome of ARID5B by AviTag protein pull-down coupled to quantitative mass spectrometry.
Among the strongest associations with pediatric B-cell acute lymphoblastic leukemia (B-ALL) are risk non-coding variants localized in the intron of ARID5B (AT-rich interaction domain 5B), a poorly characterized DNA-binding protein. In this study, we defined the interactome of ARID5B by LC-MS/MS and ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD061867 | Pride
Transcriptional repressor complex Avitag 
TranscriptomicsExpression data from HEK293 Flp-In cells constitutivly expressing FLAG-HA-tagged TRIM71 and that of the parental cell line
We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of human HEK293 Flp-In cells stably expressing TRIM71 to that of the parental cells, not expressing TRIM71 protein. Experiment was performed in ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-37713 | biostudies-arrayexpress
ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass...
ORGANISM(S): Homo Sapiens 
PXD038532 | panorama
TranscriptomicsMammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-37714 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse embryonic stem cells upon TRIM71 KD and parental ctrl cells
We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of mouse ES upon Trim71 KD versus that of the parental cells. Experiment was performed in triplicate.
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-37712 | biostudies-arrayexpress
GenomicsSeparation of transcriptional repressor and activator functions in HDAC3 [CUT&TAG]
Separation of transcriptional repressor and activator functions in HDAC3 [CUT&TAG]
PRJNA849807 | ENA
GenomicsSeparation of transcriptional repressor and activator functions in HDAC3 [RNA-Seq]
Separation of transcriptional repressor and activator functions in HDAC3 [RNA-Seq]
PRJNA849808 | ENA
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