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MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
MetabolomicsLipidome Signatures of Metastasis in a Transgenic Mouse Model of Sonic Hedgehog Medulloblastoma.
Not available
ORGANISM(S): Mus musculus 
ST001290 | MetabolomicsWorkbench
TranscriptomicsDietary calcium inhibits colitis development in HLA-B27 transgenic rats
Background and Aims: We have shown in several controlled rat and human infection studies that dietary calcium improves intestinal resistance and strengthens the mucosal barrier. Reinforcement of gut barrier function is also relevant for inflammatory bowel disease (IBD). Therefore, we investigated th...
ORGANISM(S): Rattus norvegicus 
2009-07-16 | E-GEOD-11022 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analyses of Myc-induced zebrafish liver cancer
To study the characteristics and mechanisms of Myc-induced zebrafish liver tumor, next-generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that ribosome proteins were overwhelmingly up-regulated in the Myc-induced live...
ORGANISM(S): Danio rerio 
2013-04-02 | E-GEOD-40745 | biostudies-arrayexpress
MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
ProteomicsHuman SMARCA5 interactome in transgenic SMARCA5 mouse model
We hypothesize that the ISWI ATPase Smarca5 plays a role in hematopoietic stem cell development via its interaction partners, and to study the role, we used a mouse model with transgenic expression of SMARCA5 coupled with mass spectrometry analysis. The study uses transgenic SMARCA5 mouse model with...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD049034 | Pride
Smarca5 Transgenic mice Immunoprecipitation 
TranscriptomicsHpa1Xoo-Mediated Transcriptome in Transgenic Cotton
Hpa1Xoo-Mediated Transcriptome in Transgenic Cotton Reveals the Constitutively Expressed Diverse Defense genes in Multiple Signaling Pathways Associated with Hypersensitive Cell Death Like other harpins, harpinXoo enables plants to acquire multiple resistance to pathogen and insect attack. However,...
ORGANISM(S): Gossypium hirsutum 
2010-12-01 | E-GEOD-20446 | biostudies-arrayexpress
TranscriptomicsTranscriptome alterations associated with TMV-resistance in transgenic tobacco plants expressing the genomic RNA of the virus
Agilent 4x44k tobacco micro array of wild type tobacco (WT) and whole tobacco mosaic virus (TMV) containing transgenic tobacco plants. The transgenic plants before resistance break (BRB-6 weeks), after resistance break (ARB-8 weeks) and wild type tobacco plants infected with TMV (TMVi-9weeks) leaves...
ORGANISM(S): Nicotiana tabacum 
2014-11-03 | E-MEXP-3934 | biostudies-arrayexpress
TranscriptomicsMolecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a short (GCG)8–13 expansions within the first exon of the poly(A)-binding protein nuclear 1 gene (PABPN1), leading to an expanded p...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26604 | biostudies-arrayexpress
ProteomicsThe porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-04 | PXD017274 | Pride
Differential proteomics Innate immune cell Neutrophil granulocyte Diabetes 
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