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TranscriptomicsDietary calcium inhibits colitis development in HLA-B27 transgenic rats
Background and Aims: We have shown in several controlled rat and human infection studies that dietary calcium improves intestinal resistance and strengthens the mucosal barrier. Reinforcement of gut barrier function is also relevant for inflammatory bowel disease (IBD). Therefore, we investigated th...
ORGANISM(S): Rattus norvegicus 
2009-07-16 | E-GEOD-11022 | biostudies-arrayexpress
TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of colon mucosa from HLAB27 transgenic rats fed extra-virgin olive oil rich in polyphenols
HLA-B27 transgenic rats, experimental model of chronic colitis, fed with a diet in which the lipid component was provided by corn oil (CO group), extra-virgin olive oil rich in phenols, 718.8 mg of total phenols/kg of olive oil (EVOO group) or the same extra-virgin olive oil, deprived of phenolic co...
ORGANISM(S): Rattus norvegicus 
2018-11-26 | E-MTAB-6218 | biostudies-arrayexpress
ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
TranscriptomicsGene expression in lungs from male HIV transgenic rats
HIV Tg rats exhibit pulmonary hypertension and pulmonary artery remodeling. In an effort to begin to understand cell signaling pathways which are altered in lungs from HIV transgenic rats, we used microarray analysis. n=3 samples of lung tissue from 3 month old male HIV transgenic rat and n=3 sampl...
ORGANISM(S): Rattus norvegicus 
2011-08-31 | E-GEOD-27393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of colon mucosa from HLAB27 transgenic rats fed apple-supplemented diets with low or high levels of proanthocyanidins
Transcription profiling in rats fed modified AIN76 diet, high fat/low fibre, (controls) and rats fed apple-supplemented diets, contained 7.6% of lyophilized apples with low (Golden) or high (Marie M�nard) proanthocyanidins.
ORGANISM(S): Rattus norvegicus 
2009-06-16 | E-TABM-514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats with terminal heart failure and cachexia
Rats overexpressing the human renin and angiotensinogen genes die after seven weeks of end organ damage. They develop hypertension, heart hypertrophy and proteinuria.We compared terminal heart failure, these are indeed terminally ill to double transgenic animals suffering on hypertension, proteinuri...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1557 | biostudies-arrayexpress
TranscriptomicsExpression data of CD9 positive germ cells from young and aged Sprague Dawley germ cell specific GFP rats
Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression in the spermatogonial cells at the foundation of spermatogenesis A full genome microarray was used to determine if distinct pathways of genes were alte...
ORGANISM(S): Rattus norvegicus 
2013-12-05 | E-GEOD-50143 | biostudies-arrayexpress
TranscriptomicsFumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats
Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate (DMF), exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid este...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-MTAB-2406 | biostudies-arrayexpress
TranscriptomicsTranscriptomic measurement of PVN after CNO treatment of AVP-hM3Dq-mCherry transgenic rats
Transcriptomic measurement of the paraventricular nucleus (PVN) after clozapine-N-oxide (CNO) treatment of AVP-hM3Dq-mCherry transgenic rats. At 120 min after subcutaneous injection of Saline (1 mL/kg, n = 5) or CNO (1 mg/kg, n= 5), rats were deeply anaesthetized with three types of mixed anaesthet...
ORGANISM(S): Rattus norvegicus 
2026-09-01 | E-MTAB-14688 | biostudies-arrayexpress
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