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TranscriptomicsThe Genomics of the Fetal Hypothalamic Cellular Response to Transient Hypoxia: Endocrine, Immune, and Metabolic Responses
Fetuses respond to transient hypoxia (a common stressor in utero) with cellular responses that are appropriate for promoting survival of the fetus. The present experiment was performed to identify the acute genomic responses of the fetal hypothalamus to transient hypoxia. Three fetal sheep were ex...
ORGANISM(S): Ovis aries 
2014-01-16 | E-GEOD-43371 | biostudies-arrayexpress
TranscriptomicsGATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we analyzed the effect of on gene expression upon ectopic expression of Gata1s or Gata1, while simultaneously knocking down endogenous GATA1,...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56332 | biostudies-arrayexpress
TranscriptomicsMET after transient Twist activation results in de novo gain of malignant traits
During Epithelial-Mesenchymal Transition (EMT), apical-basal polarized epithelial cells are converted to front-to-back polarized mesenchymal cells that only form loose cell-cell adhesions. These phenotypic changes are accompanied by acquisition of increased motility and invasiveness. EMT programs ar...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-61206 | biostudies-arrayexpress
GenomicsZscan4 mediates transient remodeling and transcriptional burst of heterochromatin in mouse embryonic stem cells
This SuperSeries is composed of the SubSeries listed below. Repetitive sequences such as telomeres, centromeres, and retrotransposons are packed in permanently-condensed and transcriptionally-silenced heterochromatin, whose maintenance is critical for the genome stability. We have recently found th...
ORGANISM(S): Mus musculus 
2015-09-10 | E-GEOD-51682 | biostudies-arrayexpress
ProteomicsOff-target responses in the HeLa proteome subsequent to transient plasmid transfection using SILAC
We report a significant differential expression of proteins, all of which are associated with a viral infection response typified by Interferon type I/II. Notably the upregulated proteins may affect several vital cellular processes, including cell cycle control, translation and post-translational m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-23 | MSV000079757 | MassIVE
OtherTransient expression of SPS, KOMT1, and CYP719A26 from kava
Transient expression of SPS, KOMT1, and CYP719A26 from kava (Piper methysticum)
ORGANISM(S): Nicotiana Benthamiana 
2018-12-22 | MSV000083275 | MassIVE
TranscriptomicsTranscription profiling of humans to investigate between transient vs acute megakaryoblastic leukaemia (TMD vs AMKL) in Downs syndrome
Comparison of transient myeloproliferative disorder and acute megakaryoblastic leukaemia in Down syndrome.
ORGANISM(S): Homo sapiens 
2004-09-01 | E-MEXP-72 | biostudies-arrayexpress
TranscriptomicsMERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs
Several previous studies have noted a rare sub-population of murine Embryonic Stem Cells (mESCs) which seem to express genes otherwise specific to the 2-cell stage of embryonic development. Here we sorted single cells from a MERVL/Zscan4 reporter line to investigate the continuum of expression as ce...
ORGANISM(S): Mus musculus 
2016-09-30 | E-MTAB-5058 | biostudies-arrayexpress
Metabolomics,MultiomicsGNPS - Transient expression of SPS, KOMT1, and CYP719A26 from kava
Transient expression of SPS, KOMT1, and CYP719A26 from kava (Piper methysticum)
ORGANISM(S): Nicotiana Benthamiana (ncbitaxon:4100) 
2018-12-22 | MSV000083275 | GNPS
TranscriptomicsThe Histone Deacetylase Rpd3p Coordinates Transient Changes in Genomic Expression in Response to Acute Stress
To characterize the role of chromatin remodeling proteins in mediating stress-activated expression changes, whole-genome expression was followed in wild-type and mutant cells (including strains lacking the histone deacetylase Rpd3p, associated Rpd3p proteins, and the transcription factors Msn2p and ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-05-20 | E-GEOD-9108 | biostudies-arrayexpress
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