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Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Ribosome stalling, spacing and A-site occupancy impact translation and co-translational mRNA decay in plants
This study investigates the immediate effects of single, double, and triple branched-chain amino acid (BCAA) deprivation on translational dynamics in NIH3T3 cells. Using a multi-omics approach combining RNA-seq, ribosome profiling (Ribo-seq), quantitative proteomics, and tRNA charging assays, we sys...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-13 | PXD067949 | Pride
Background Cells regulate protein synthesis in response to fluctuating nutrient availability through mechanisms that affect both translation initiation and elongation. Branched-chain amino acids, leucine, isoleucine, and valine, are essential nutrients. However, how their depletion affects translati...
ORGANISM(S): Mus musculus 
2025-09-02 | GSE291653 | GEO
Background: Cells regulate protein synthesis in response to fluctuating nutrient availability through mechanisms that affect both translation initiation and elongation. Branched-chain amino acids, leucine, isoleucine, and valine, are essential nutrients. However, how their depletion affects translat...
ORGANISM(S): Mus musculus 
2025-09-02 | GSE291652 | GEO
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