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MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
MetabolomicsThe Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here we used TurboID and genome engineering to identify apicop...

2024-01-15 | MTBLS7060 | MetaboLights
MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
Genomicstransporters
Arabidopsis thaliana mutant lines of secondary metabolite transporters microbiome
PRJEB65466 | ENA
Genomicsfungal monosaccharide transporters
Datamining and functional environmental genomics reassesses the phylogenetics and functional diversity of fungal monosaccharide transporters
PRJEB39531 | ENA
TranscriptomicsGlobal Expression of Molecular Transporters in the Human Vaginal Tract
Pre-exposure chemoprophylaxis using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters in the human vaginal tract may play a pivotal role in determining drug disposition and, consequently, pharmacodynamic outcomes in these eff...
ORGANISM(S): Homo sapiens 
2014-01-29 | E-GEOD-49892 | biostudies-arrayexpress
TranscriptomicsIdentification of plant vacuolar transporters mediating phosphate storage
Plant vacuoles serve as the primary intracellular compartments for inorganic phosphate (Pi) storage. Passage of Pi across vacuolar membranes plays a critical role in buffering the cytoplasmic Pi level against fluctuations of external Pi and metabolic activities. Here we demonstrate that the SPX-MFS ...
ORGANISM(S): Arabidopsis thaliana 
2016-03-28 | E-GEOD-74856 | biostudies-arrayexpress
GenomicsTranscriptome analysis of pathways and drug transporters after hyperosmotic stress of renal MDCK I cells
Transcriptome analysis of pathways and drug transporters after hyperosmotic stress of renal MDCK I cells
PRJNA433403 | ENA
ProteomicsAn impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters
We integrated metabolome and proteome profiles of the parental cell line 143B.TK- versus ?0, including PTM analyses such as phosphorylation and ubiquitination to characterize the impact of the absence of mtDNA for the entire cell. For quantitative proteome profiling, we used a shotgun LC-MS/MS appro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080873 | MassIVE
GenomicsHepatocyte Nuclear Factors 4a and 1a (Hnf4a and Hnf1a) Regulate Kidney Developmental Expression of Drug-Metabolizing Enzymes and Drug Transporters
The transcriptional regulation of drug-metabolizing enzymes and transporters (here collectively referred to as DMEs) in the developing proximal tubule is not well understood. As in the liver, DME regulation in the PT may be mediated through nuclear receptors which are thought to “sense” deviations f...
ORGANISM(S): Rattus norvegicus 
2014-01-01 | E-GEOD-50815 | biostudies-arrayexpress
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