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ProteomicsTransportin-1 (TRN-1) orchestrates HIV-1 uncoating and nuclear import
Timely uncoating and nuclear import are key to efficient HIV infection, however the triggers and mechanisms that orchestrate these steps are unknown. Here we show that HIV-1 exploits Transportin-1/TRN-1 for both uncoating and nuclear import. Depletion of TRN-1, which we characterised by mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD010023 | Pride
Trn-1 Co-immunoprecipitation Human Transportin-1 Hiv Nuclear import Orbitrap fusion 
ProteomicsTransportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein
The nitric oxide synthase interacting protein (NOSIP), an E3-ubiquitin ligase, is involved in various processes like neuronal development, craniofacial development, granulopoiesis, mitogenic signaling, apoptosis and cell proliferation. The best characterized function of NOSIP is the regulation of eN...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033966 | Pride
Transportin Nuclear import 
UnknownTransportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.
Not available
S-EPMC9974451 | biostudies-literature
UnknownThe requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.
Not available
S-EPMC2798409 | biostudies-literature
UnknownThe host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.
Not available
S-EPMC3536424 | biostudies-literature
UnknownTumor suppressor BAP1 nuclear import is governed by transportin-1.
Not available
S-EPMC9036092 | biostudies-literature
TranscriptomicsNAT10 inhibition improves cellular phenotypes of Hutchinson-Gilford progeria syndrome by restoring the Transportin-1 pathway
In this experiment, we aim to examine the role of NAT10 inhibition in Hutchinson-Gilford progeria syndrome (HGPS), a rare but devastating premature ageing syndrome caused by a mutation in the LMNA gene. NAT10 inhibition improves HGPS cellular phenotypes by releasing Transportin-1 (TNPO1) from the cy...
ORGANISM(S): Homo sapiens 
2018-06-25 | E-MTAB-6651 | biostudies-arrayexpress
UnknownCRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import.
Not available
S-EPMC8510174 | biostudies-literature
UnknownTransportin-1: A Nuclear Import Receptor with Moonlighting Functions.
Not available
S-EPMC7930572 | biostudies-literature
UnknownInteraction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Not available
S-EPMC3464514 | biostudies-literature
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