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ProteomicsTransportin-1 (TRN-1) orchestrates HIV-1 uncoating and nuclear import
Timely uncoating and nuclear import are key to efficient HIV infection, however the triggers and mechanisms that orchestrate these steps are unknown. Here we show that HIV-1 exploits Transportin-1/TRN-1 for both uncoating and nuclear import. Depletion of TRN-1, which we characterised by mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD010023 | Pride
Trn-1 Co-immunoprecipitation Human Transportin-1 Hiv Nuclear import Orbitrap fusion 
UnknownThe HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.
Not available
S-EPMC4155696 | biostudies-literature
UnknownInteraction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Not available
S-EPMC3464514 | biostudies-literature
TranscriptomicsDC immunotherapy in HIV-1 infection induces a major blood transcriptome shift
Objective: This study aimed to evaluate the effect of dendritic cell (DC) vaccination against HIV-1 on host gene expression profiles. Design: Longitudinal PBMC samples were collected from participants of the DC-TRN trial for immunotherapy against HIV. Microarray-assisted gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-MTAB-3296 | biostudies-arrayexpress
TranscriptomicsFFPE study using MIP copy number platform
This SuperSeries is composed of the following subset Series: GSE14740: FFPE study using MIP copy number platform - kidney GSE14741: FFPE study using MIP copy number platform - bladder/colorectal/kidney/liver GSE14742: FFPE study using MIP copy number platform - colorectal GSE14743: FFPE study using ...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-14856 | biostudies-arrayexpress
TranscriptomicsFFPE study using MIP copy number platform - colorectal
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate fresh frozen samples and thus a dependence on Formalin-Fixed Paraffin Embedded (FFPE) banked samples, which typically have more extensive clinical follow up information. However, on most hig...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-14742 | biostudies-arrayexpress
TranscriptomicsFFPE study using MIP copy number platform - liver
: A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate fresh frozen samples and thus a dependence on Formalin-Fixed Paraffin Embedded (FFPE) banked samples, which typically have more extensive clinical follow up information. However, o...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-14745 | biostudies-arrayexpress
TranscriptomicsFFPE study using MIP copy number platform - kidney
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate fresh frozen samples and thus a dependence on Formalin-Fixed Paraffin Embedded (FFPE) banked samples, which typically have more extensive clinical follow up information. However, on most hig...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-14740 | biostudies-arrayexpress
TranscriptomicsFFPE study using MIP copy number platform - bladder/colorectal/kidney/liver
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate fresh frozen samples and thus a dependence on Formalin-Fixed Paraffin Embedded (FFPE) banked samples, which typically have more extensive clinical follow up information. However, on most hig...
ORGANISM(S): Homo sapiens 
2009-02-17 | E-GEOD-14741 | biostudies-arrayexpress
TranscriptomicsMBL-1/Muscleblind regulates neuronal differentiation and controls the splicing of a terminal selector in Caenorhabditis elegans
The muscleblind family of mRNA splicing regulators is conserved across species and regulate the development of muscles and the nervous system. However, how Muscleblind proteins regulate neuronal fate specification and neurite morphogenesis at the single-neuron level is not well understood. In this s...
ORGANISM(S): Caenorhabditis elegans 
2024-08-14 | GSE274472 | GEO
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