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GenomicsGenome wide exon trapping
Genome wide exon trapping
PRJNA878769 | ENA
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014839 | Pride
Rucaparib Hela cell Irucaparib Parp trapping Chromatin 
ProteomicsA substrate trapping approach identifies proteins regulated by reversible S-nitrosylation
In this study we adapted the Trx trapping strategy for global profiling of cellular nitrosylation/denitrosylation processes. Using this approach, we report the identification of hundreds of potential new nitrosylated targets in monoctyes and macrophages followed by validation using biochemical and f...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-07-02 | PXD001001 | Pride
Proteomics Human S-nitrosylation 
GenomicsAntibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus
Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus
PRJNA1244296 | ENA
ProteomicsDeceptive Ceropegia sandersonii uses an arabinogalactan for trapping its fly pollinators
Many plant species have evolved surfaces designed to reduce insect attachment. Among such plants are deceptive trap flowers of Ceropegia. Their gliding zones consist of epidermal cells each topped by a papilla secreting a single small liquid droplet on its tip. So far, the molecular and physical mec...
ORGANISM(S): Ceropegia sandersonii 
2025-04-11 | PXD062347 | Pride
Nmr spectroscopy Anti-adhesive surface Peptide mapping Mass spectrometry Agp Polysaccharide Ceropegia sandersonii Monosaccharide composition Fly-trapping flower 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014836 | Pride
Hela cell Irucaparib-tp3 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-01 | PXD014838 | Pride
Primary neonatal rat cardiomyocyte Irucaparib Irucaparib-tp5 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014840 | Pride
Rucaparib Parylated proteome Hela cell Irucaparib-tp3 Irucaparib 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014837 | Pride
Bt-549 cell Vrucaparib-tp4 Irucaparib-tp3 Parp1 degradation 
ProteomicsChasing protein arginine phosphorylation: development of a selective enrichment method using a trapping mutant phosphatase
Proof-of-principle pull-down experiments using a YwlE trapping mutant phosphatase to selective capture arginine phosphorylated proteins. Phosphoarginine is an acid labile protein modification that was demonstrated to exist in bacteria and probably also in higher eukaryotes. Due to the high abundance...
ORGANISM(S): Bacteria Bacillus subtilis subsp. subtilis str. 168 
2014-05-19 | PXD000560 | Pride
Arginie phosphorylation Trapping mutant phosphatase 
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