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Transcription profiles were obtained for 2-month old mice containing an expanded or normal CAG trinucleotide repeat in the coding region for TATA-binding protein (TBP). Three different genotypes were used : TBP-13Q (normal), TBP-71Q (71 repeats), and TBP-105Q (105 repeats). Two lines of TBP-71Q (li...
ORGANISM(S): Mus musculus 
We have done RNAseq analyses in yeast and in rat and mouse striatal neurons. The experiments in yeast examine globally the physiological effects of spt4 deletion on the transcriptome. The experiments in neurons examine the global effects of supt4 knockdown to a cellular level (i.e., 50% knockdown)...
ORGANISM(S): Rattus norvegicus 
Evidence for toxic CAG trinucleotide repeats contributing to Huntington’s disease though RNA interference
Evidence for toxic CAG trinucleotide repeats contributing to Huntington’s disease though RNA interference
Evidence for toxic CAG trinucleotide repeats contributing to Huntington’s disease though RNA interference
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