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ProteomicsExome reanalysis and proteomic profiling identified TRIP4 as a novel cause of cerebellar hypoplasia and spinal muscular atrophy (PCH1)
TRIP4 is one of the subunits of the transcriptional coregulator ASC-1, a ribonucleoprotein complex that participates in transcriptional coactivation and RNA processing events. Recessive variants in the TRIP4 gene have been associated with spinal muscular atrophy with bone fractures as well as a sev...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023584 | Pride
Proteogenomics Pch1 Solve-rd Exome reanalysis Trip4 
UnknownExome reanalysis and proteomic profiling identified TRIP4 as a novel cause of cerebellar hypoplasia and spinal muscular atrophy (PCH1).
Not available
S-EPMC8440675 | biostudies-literature
Unknown'A novel TRIP4 Variant Associated with Peripheral Neuropathy: Expanding the Clinical and Genetic Spectrum of ASC1-Related Myopathy'.
Not available
S-EPMC10789366 | biostudies-literature
UnknownBAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma.
Not available
S-EPMC12320230 | biostudies-literature
ProteomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
Dysregulation of the NF-κB pathway is frequently observed in cancers, where it contributes to therapy resistance by inhibiting apoptosis. Mass spectrometry (MS)-based proteomics were employed to identify factors associated with the anti-apoptotic process. We identify RNF25, an E3 ubiquitin ligase, a...
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061521 |
UnknownFollow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene.
Not available
S-EPMC3944635 | biostudies-literature
UnknownTargeting MED8 enhances sorafenib sensitivity in hepatocellular carcinoma by disrupting epithelial-mesenchymal transition mechanisms.
Not available
S-EPMC12541920 | biostudies-literature
UnknownExtended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex.
Not available
S-EPMC10076317 | biostudies-literature
ProteomicsExtended DNA threading through a dual-engine motor module in the activating signal co-integrator complex
Activating signal co-integrator complex (ASCC) supports diverse genome maintenance and gene expression processes. Its ASCC3 subunit is an unconventional nucleic acid helicase, harboring tandem Ski2-like NTPase/helicase cassettes crucial for ASCC functions. Presently, the molecular mechanisms underly...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD036106 | Pride
Protein-dna cross-linking 
UnknownMutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.
Not available
S-EPMC4800037 | biostudies-literature
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